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Abstract

Background, The aim of this study was to assess the clinical presentation, risk factors, and comorbidities of the patients with Staphylococcus aureus bacteriuria, and to analyze the antimicrobial susceptibility data of S. aureus isolated from their urine samples. Methods, A total of 80 isolates of S. aureus were collected from patients with urinary tract infections (UTIs)in hospital Refai. Urinalysis was performed manually, including macroscopic examination of color and appearance, and microscopic examination for the presence of urinary  pus cells, and bacteria and culture on MaCconky agar,Blood agar. Full diagnosis and susceptibility testing of S. aureus were performed by the VITEK 2 system (BioMérieux, Marcy-l'Étoile, France) using standard criteria. Results, The majority of the patients were female (50), with a mean age of 30 years and male(30) mean ageof45 years  . Most of the patients were inhospatial . Seventy positive urine cultures were associated with UTI symptoms. ButTen negative urine cultures. Conclusion, Although S. aureus UTI is known to be associated with other risk factors such as urinary catheterization, long hospital stay, or complicated UTI, our results show the community-acquired presentation of UTI. Trimethoprim-sulfamethoxazole may be used as an effective treatment for UTI caused by S. aureus. S. aureus UTI could be an alarming sign of more invasive infections such as S. aureus bacteremia, though clinical evaluation and finding the source of S. aureus are crucial for effective treatment and prevention of further complications

Keywords

antibiotic resistance urine culture urinary tract infection bacteriuria staphylococcus aureus

Article Details

How to Cite
Jaber, S. A. A. (2024). VITEK2 BASED DIAGNOSIS AND CHARACTERIZATION STAPHYLOCOCCI AERUS STRAIN CAUSING URINARY TRACT INFECATION IN FEMAL AND MALE. Journal of Medical Genetics and Clinical Biology, 1(8), 298–302. https://doi.org/10.61796/jmgcb.v1i8.860

References

  1. . Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr. Clin Microbiol Rev. 2015;28:603–661. [PMC free article] [PubMed] [Google Scholar]
  2. . Characterization of Staphylococcus aureus biofilm formation in urinary tract infection. Yousefi M, Pourmand MR, Fallah F, Hashemi A, Mashhadi R, Nazari-Alam A. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888176/ Iran J Public Health. 2016;45:485–493. [PMC free article] [PubMed] [Google Scholar]
  3. . Clinical risk factors for methicillin-resistant Staphylococcus aureus bacteriuria in a skilled-care nursing home. Coll PP, Crabtree BF, O'Connor PJ, Klenzak S. Arch Fam Med. 1994;3:357–360. [PubMed] [Google Scholar]
  4. . Staphylococcus aureus bacteriuria. Demuth PJ, Gerding DN, Crossley K. Arch Intern Med. 1979;139:78–80. [PubMed] [Google Scholar]
  5. . Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent staphylococcal bacteremia. Muder RR, Brennen C, Rihs JD, Wagener MM, Obman A, Stout JE, Yu VL. Clin Infect Dis. 2006;42:46–50. [PubMed] [Google Scholar]
  6. . Cost effect of managing methicillin-resistant Staphylococcus aureus in a long-term care facility. Capitano B, Leshem OA, Nightingale CH, Nicolau DP. J Am Geriatr Soc. 2003;51:10–16. [PubMed] [Google Scholar]
  7. . Primary Staphylococcus aureus urinary tract infection: the role of undetected hematogenous seeding of the urinary tract. Baraboutis IG, Tsagalou EP, Lepinski JL, Papakonstantinou I, Papastamopoulos V, Skoutelis AT, Johnson S. Eur J Clin Microbiol Infect Dis. 2010;29:1095–1101. [PubMed] [Google Scholar]
  8. . Leber AL. Clinical Microbiology Procedures Handbook. Clin Microbiol Proced Handb. Published Online First: 15 May. Hoboken, NJ: Wiley; 2016. Clinical Microbiology Procedures Handbook. [Google Scholar]
  9. . Antibiotic susceptibility of bacterial strains isolated from patients with community-acquired urinary tract infections in France. Multicentre Study Group. Goldstein FW. Eur J Clin Microbiol Infect Dis. 2000;19:112–117. [PubMed] [Google Scholar]
  10. . Antibiotic sensitivity of bacteria associated with community-acquired urinary tract infection in Britain. Barrett SP, Savage MA, Rebec MP, Guyot A, Andrews N, Shrimpton SB. J Antimicrob Chemother. 1999;44:359–365. [PubMed] [Google Scholar]