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Abstract
Background: Opportunistic enterobacteria (OE), including various Gram-negative bacteria, are known to cause infections, particularly in immunocompromised individuals. Specific Background: Despite their clinical relevance, there is limited data on the prevalence of antibodies against these bacteria in the general adult population. Knowledge Gap: The extent to which antibodies to opportunistic enterobacteria are present in serum samples from healthy adults has not been thoroughly investigated. Aims: This study aimed to evaluate the presence and frequency of antibodies to seven types of Gram-negative opportunistic enterobacteria in adult serum samples using enzyme-linked immunosorbent assay (ELISA). Results: The analysis revealed a significant prevalence of antibodies against the bacteria E. coli, Proteus vulgaris, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, and Pseudomonas aeruginosa among the subjects. Novelty: This research provides new insights into the widespread presence of antibodies to OE in a healthy adult population, highlighting previously underexplored immunological responses. Implications: These findings could enhance diagnostic approaches and inform treatment strategies for infections caused by opportunistic enterobacteria, potentially leading to improved management of such infections in clinical settings.
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References
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References
Vershihora, A.E. General Immunology. Kyiv: Vyscha shkola, 1989. 736 p.
Kovalchuk, L.R., Cheredeev, A.N. Actual problems of human immune system assessment at the present stage // Immunology. – 1990. – No.5. – P.4-7.
Belyakov, I.M. Immune system of mucous membranes // Immunology. – 1997. - No.4. - P.7-13.
Immunosorbent assay system for determination of staphylococcal enterotoxin type C / Fluer F.S., Prokhorov V.Ya., Vesnina A.F., Akatov A.K. // Journal of Microbiology. – 2002. - No.6. – P.65-68.
Highly sensitive immunochemical method for determination of autoantibodies to endometrial tissue antigen and its use in the diagnosis of gynecological diseases / Khoklov P.P., Mikhnina E.A., Kalinina N.M. and co-authors // Medical Immunology. – 2007. – Vol.9. - No.2-3. – P.268-269.
Kostinov M.P., Tarasova A.A., Zaytsev E.M. Content of antibodies to Bordetella pertussis antigens in patients with rheumatic diseases // ZhMEI. – M., 2007. – No.6. – P.661-64.