MODERN USE OF DRUGS IN BRONCHOPULMONARY PATHOLOGY

Rihsi Abdumavljanovna Azizova; Tamila  Abdulazizovna Valieva

doi:10.61796/jmgcb.v1i11.1042

Authors

Rihsi Abdumavljanovna Azizova
rishi@gmail.com
Department of Family Medicine 2 Clinical Pharmacology, Tashkent Pediatric Medical Institute
Tamila Abdulazizovna Valieva

Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology

Articles

November 11, 2024

Downloads

View Article

Abstract
How to Cite
Metrics
References
License

Objective: This study aims to evaluate the rational pharmacotherapy for bronchopulmonary diseases in children with recurrent bronchitis, focusing on treatment effectiveness and safety. Methods: A retrospective analysis of 28 children aged 1.5 to 10 years, diagnosed with acute bronchitis, recurrent bronchitis, and pneumonia, was conducted. The patients were treated at a pulmonology department and underwent clinical, laboratory, and radiological assessments. Treatment regimens included third-generation cephalosporins, glucocorticoids, and antihistamines, administered according to age-based standards. Results: The study revealed that all patients exhibited moderate symptoms upon admission, with many presenting coexisting conditions such as chronic ENT diseases and iron-deficiency anemia. Clinical laboratory tests indicated iron deficiency anemia and mild leukocytosis across all groups, suggesting impaired oxygen delivery and ongoing inflammation. The pharmacotherapy was generally well-tolerated, with notable improvements in respiratory function and recovery in most children. Novelty: This study highlights the importance of personalized pharmacotherapy in managing recurrent bronchitis in children, particularly considering comorbid conditions. It emphasizes the role of comprehensive treatment protocols integrating antibiotics, glucocorticoids, and antihistamines for effective management.

Abdumavljanovna Azizova, R., & Abdulazizovna Valieva, T. (2024). MODERN USE OF DRUGS IN BRONCHOPULMONARY PATHOLOGY. Journal of Medical Genetics and Clinical Biology, 1(11), 50–55. https://doi.org/10.61796/jmgcb.v1i11.1042

Download Citation

R. A. Azizova, M. I. Mukhitdinova, and A. O. Abdullaev, “Effective and Safe Pharmacotherapy for Bronchopulmonary Diseases in Children,” Education and Science in the 21st Century, vol. 5, no. 25, pp. 1587, Apr. 2022.

World Health Organization, "Rational Use of Medicines," 62nd World Health Assembly, Geneva, 2009, Resolution WHA60/16, WHO Technical Report Series no. 950.

M. G. Romantsov and F. I. Ershov, Frequently Ill Children: Modern Pharmacotherapy – A Guide for Physicians, Moscow: GEOTAR-Media, 2006.

A. G. Chuchalin et al., “Pulmonology,” no. 3, pp. 15, 2014.

E. Eber and F. Midulla, Eds., ERS Handbook of Paediatric Respiratory Medicine, 2013. DOI: 10.1183/9781849840392-hbp01, ISBN (electronic): 978-1-84984-039-2.

V. K. Tatochenko, Diseases of the Respiratory Organs (Practical Guide), Moscow: Pediatr, 2012.

P. Di Filippo, A. Scaparrotta, M. I. Petrosino et al., “An Underestimated Cause of Chronic Cough: The Protracted Bacterial Bronchitis,” Ann Thorac Med., vol. 13, no. 1, pp. 7-13, 2018. DOI: 10.4103/atm.ATM_12_17.

B. R. Celli and W. E. MacNee, “Hoog J.C.,” Lancet, vol. 364, p. 709, 2004.

I. B. Mikhailov, Clinical Pharmacology, 2nd ed., St. Petersburg: Folio, 2000.

A. Z. Musina, N. A. Seitmagambetova, and L. M. Zhamalieva, “Indicators for Evaluating the Rationality of Drug Therapy,” Science and Health, no. 2, pp. 29-46, 2016.

A. G. Chuchalin et al., “Modern Classification of Clinical Forms of Bronchopulmonary Diseases in Children,” Pediatrics: Journal of G. N. Speransky, no. 4, 2010.

A. B. Chang, J. W. Upham, I. B. Masters et al., “Protracted Bacterial Bronchitis: The Last Decade and the Road Ahead,” Pediatric Pulmonology, vol. 51, no. 3, pp. 225-242, 2016. DOI: 10.1002/ppul.23351.

N. T. T. Nhung, C. Schindler, T. M. Dien, N. Probst-Hensch, L. Perez, and N. Künzli, “Acute Effects of Ambient Air Pollution on Lower Respiratory Infections in Hanoi Children: An Eight-Year Time Series Study,” Environmental International, vol. 110, pp. 139-148, 2018.

S. I. Ovcharenko and V. I. Leshchenko, Chronic Obstructive Pulmonary Disease: A Guide for Practitioners, edited by A. G. Chuchalin, Moscow, 2016, p. 129.

A. B. Chang, C. F. Robertson, P. P. Van Asperen et al., “A Multicenter Study on Chronic Cough in Children: Burden and Etiologies Based on a Standardized Management Pathway,” Chest, vol. 142, no. 4, pp. 943-950, 2012. DOI: 10.1378/chest.11-2725.

M. I. Mukhitdinova, R. A. Azizova, and B. A. Karabekova, “Problems of Rational Drug Use,” Biomedicine and Practice, no. 3, 2021. DOI: 10.26739/2181-9300.

S. S. Postnikov, “Pediatric Aspects of Clinical Pharmacology,” Medical Practice, no. 3, pp. 4-13, 2012.

R. A. Azizova, M. I. Mukhitdinova, B. A. Karabekova, and K. Sh. Shoabidova, “Rational Pharmacotherapy in Children with Bronchitis,” Chin J Ind Hyg Occup Dis, vol. 39, no. 13, pp. 313-318, 2021.