HISTOMORPHOLOGY OF KIDNEY OF EXPERIMENTAL ANIMALS AFTER MELOXICAM ADMINISTRATION

Raghad Kh. Ibraheem Al. Jubory

doi:10.61796/jmgcb.v2i3.1181

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Raghad Kh. Ibraheem Al. Jubory
raghadal.jubory@uokikuk.edu.iq
Department of Basic Medical Sciences, College of Dentistry, University of Kirkuk, Iraq

Vol. 2 No. 3 (2025): Journal of Medical Genetics and Clinical Biology

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November 11, 2024

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Objective: This study investigates the deleterious effects of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically meloxicam, on renal tissue in albino rats. Methods: Sixteen Sprague Dawley albino rats were divided into two groups: Group A received normal saline, while Group B was administered meloxicam at a dose of 15 mg/kg/day via a feeding tube for 14 days. On day 15, all animals were sacrificed, and their kidneys were extracted, preserved, and sectioned. The kidney samples were stained with silver methenamine, PAS, and H&E, and renal histology was examined under a light microscope to assess changes in the renal tubules. Results: The study found that meloxicam caused significant damage to the distal and proximal convoluted tubules in Group B rats. Notable histological changes included tubule dilatation, epithelial flattening, rupture of the brush border in proximal tubules, and thickening of the basement membrane surrounding the tubular epithelium. Novelty: This research highlights the nephrotoxic effects of meloxicam, a commonly used NSAID, providing new insights into its potential harmful impact on renal health, which has not been widely emphasized in previous studies on its adverse effects.

Kh. Ibraheem Al. Jubory, R. (2024). HISTOMORPHOLOGY OF KIDNEY OF EXPERIMENTAL ANIMALS AFTER MELOXICAM ADMINISTRATION. Journal of Medical Genetics and Clinical Biology, 2(3), 1–8. https://doi.org/10.61796/jmgcb.v2i3.1181

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