BIOACTIVE COMPOUNDS IN MEDICINAL PLANTS AS A SOURCE OF ANTI-PARASITIC: REVIEW ARTICLE

Abdullah Zaidan Khalaf Al-Quraghuli; Jassim Mohammed Ali

doi:10.61796/jmgcb.v2i11.1442

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Abdullah Zaidan Khalaf Al-Quraghuli
azidan@gmail.com
Presidency of Sunni Endowment Diwan / Department of Religious Education and Islamic Studies, Dhul-Nurayn Islamic Secondary School
Jassim Mohammed Ali Department of Chemistry, College of Education for Pure Sciences, University of Kirkuk, Kirkuk, Iraq

Vol. 2 No. 11 (2025): Journal of Medical Genetics and Clinical Biology

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September 12, 2025

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Objective: Despite the considerable worldwide health and economic burden imposed by gastrointestinal parasites in humans and cattle, treatment alternatives are increasingly hindered by multidrug resistance and the detrimental effects of synthetic medications. Method: This review encapsulates the antiparasitic potential of medicinal plants and their phytochemicals, elucidates their modes of action and pharmacological relevance, and examines their position as a possible source for next-generation antiparasitic therapeutics. Results: Medicinal plants, abundant in structurally varied bioactive chemicals including flavonoids, alkaloids, terpenoids, tannins, and essential oils, have historically served as significant sources of medicinal medicines. Novelty: This review encapsulates the antiparasitic potential of medicinal plants and their phytochemicals, elucidates their modes of action and pharmacological relevance, and examines their position as a possible source for next-generation antiparasitic therapeutics.

Al-Quraghuli, A. Z. K., & Ali, J. M. (2025). BIOACTIVE COMPOUNDS IN MEDICINAL PLANTS AS A SOURCE OF ANTI-PARASITIC: REVIEW ARTICLE. Journal of Medical Genetics and Clinical Biology, 2(11), 499–510. https://doi.org/10.61796/jmgcb.v2i11.1442

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S. R. Hasan, F. M. Junaid, B. M. Mahdi, and F. K. Hussein, “Therapeutic applications of medicinal plants for the treatment of human intestinal diarrhea: Review article,” S. Asian J. Life Sci., vol. 13, pp. 20–24, 2025, doi: https://dx.doi.org/10.17582/journal.sajls/2025/13.20.24.

F. K. Hussein, A. J. Mahmoud, and B. J. Yousif, “Estimation of Immunoglobulin A, Immunoglobulin G, and Immunoglobulin M Antibody Levels in Laboratory Mice Balb/c Infected with Entamoeba histolytica and Treatment with Aqueous Extracts of Cyperus rotundus and Thymus serpyllum,” Polytechnic Journal, vol. 10, no. 1, p. 21, 2020, doi: https://doi.org/10.25156/ptj.v10n1y2020.pp126-129.

A. Kaushik et al., “Antiprotozoal Agents-Integration of Drug Discovery, Medicinal Chemistry, and Advanced Computational Approaches: An In-depth review,” The Microbe, p. 100395, 2025, doi: https://doi.org/10.1016/j.microb.2025.100395.

S. R. Hasan, F. K. Hussein, and F. M. Junaid, “Study of Cutaneous leishmaniasis risk factors among individuals visiting health centers in Kirkuk Governorate,” J. Adv. Parasitol., vol. 11, pp. 25–30, 2024, doi: https://dx.doi.org/10.17582/journal.jap/2024/11.25.30.

M. T. El-Saadony et al., “Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits-a comprehensive review,” Front. Immunol., vol. 16, p. 1491777, 2025.

S. Ranasinghe, A. Armson, A. J. Lymbery, A. Zahedi, and A. Ash, “Medicinal plants as a source of antiparasitics: an overview of experimental studies,” Pathog. Glob. Health, vol. 117, no. 6, pp. 535–553, 2023, doi: https://doi.org/10.1080/20477724.2023.2179454.

F. Roeber, A. R. Jex, and R. B. Gasser, “Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance-an Australian perspective,” Parasites Vectors, vol. 6, no. 1, p. 153, 2013, doi: https://doi.org/10.1186/1756-3305-6-153.

L. Mascarini-Serra, “Prevention of soil-transmitted helminth infection,” J. Glob. Infect. Dis., vol. 3, no. 2, pp. 175–182, 2011, doi: https://doi.org/10.4103/0974-777X.81696.

World Health Organization, Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition. Geneva, 2013.

M. Wink, “Medicinal plants: a source of anti-parasitic secondary metabolites,” Molecules, vol. 17, no. 11, pp. 12771–12791, 2012, doi: https://doi.org/10.3390/molecules171112771.

M. Wink, Annual plant reviews, functions and biotechnology of plant secondary metabolites. Hoboken, NJ: John Wiley & Sons, 2010.

F. Roeber, A. R. Jex, and R. B. Gasser, “Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance-an Australian perspective,” Parasites Vectors, vol. 6, no. 1, p. 153, 2013.

J. Lane, T. Jubb, R. Shephard, J. Webb-Ware, and G. Fordyce, Priority list of endemic diseases for the red meat industries. 2015.

J. Charlier et al., “Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe,” Prev. Vet. Med., vol. 182, p. 105103, 2020.

L. Mascarini-Serra, “Prevention of soil-transmitted helminth infection,” J. Glob. Infect. Dis., vol. 3, no. 2, pp. 175–182, 2011.

WHO, “Soil-transmitted helminth infections fact sheet,” 2020. [Online]. Available: https://www.who.int/en/newsroom/fact-sheets/detail/soil-transmitted-helminth-infections.

A. Dowling, J. O’Dwyer, and C. Adley, “Antibiotics: mode of action and mechanisms of resistance,” Antimicrob. Res.: Novel Bioknowledge and Educational Programs, vol. 1, pp. 536–545, 2017.

O. O. Olaleye, D. H. Kim, and K. A. Spriggs, “Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells,” BMC Complement. Med. Ther., vol. 24, no. 1, p. 110, 2024.

S. M. Humayun Akhter et al., “Green Synthesis of metal oxide nanoparticles using Plumbago zeylanica root extract, spectrochemical characterization, and antibacterial activity against common pathogen,” Appl. Res., vol. 4, no. 1, p. e202400200, 2025.

B. N. Guedes et al., “Natural antibiotics against antimicrobial resistance: sources and bioinspired delivery systems,” Braz. J. Microbiol., vol. 55, no. 3, pp. 2753–2766, 2024.

C. C. S. Martignago et al., “Exploring antibacterial properties of marine sponge-derived natural compounds: a systematic review,” Mar. Drugs, vol. 23, no. 1, p. 43, 2025.

N. Rousta, M. Aslan, M. Y. Akbas, F. Ozcan, T. Sar, and M. J. Taherzadeh, “Effects of fungal based bioactive compounds on human health,” Crit. Rev. Food Sci. Nutr., vol. 64, no. 20, pp. 7004–7027, 2024.

D. Djilianov et al., “Resurrection Plants—A Valuable Source of Natural Bioactive Compounds: From Word-of-Mouth to Scientifically Proven Sustainable Use,” Metabolites, vol. 14, no. 2, p. 113, 2024.

M. Nazish et al., “Assessment of the antimicrobial potential of the selected phytochemically riched medicinal plants against the antibiotic resistant pathogenic bacterial strains,” Not. Bot. Horti Agrobot. Cluj-Napoca, vol. 53, no. 1, pp. 14197–14197, 2025.

X. Gu, H. Wang, K. Li, C. Wu, and X. Di, “A novel strategy for identifying hepatotoxic constituents in traditional Chinese medicine using dose-normalized intracellular accumulation as a cytotoxicity indicator: a case study of Jinlingzi San,” Front. Pharmacol., vol. 16, p. 1585186, 2025.

N. H. Goki, Z. A. Tehranizadeh, M. R. Saberi, B. Khameneh, and B. S. Bazzaz, “Structure, function, and physicochemical properties of pore-forming antimicrobial peptides,” Curr. Pharm. Biotechnol., vol. 25, no. 8, pp. 1041–1057, 2024.

Y. Gou et al., “Viable but nonculturable state in the zoonotic pathogen Bartonella henselae induced by low-grade fever temperature and antibiotic treatment,” Front. Cell. Infect. Microbiol., vol. 14, p. 1486426, 2024.

P. B. Bloland, Drug resistance in malaria. 2001.

F. Roeber, A. R. Jex, and R. B. Gasser, “Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants,” Biotechnol. Adv., vol. 31, no. 8, pp. 1135–1152, 2013.

M. M. Bakr, H. M. Taher, F. K. Hussein, and A. H. Mohamed, “Study the effective role of metronidazole nanoemulsion for the treatment of skin lesions in mice induced by entamoeba histolytica,” South Asian Res. J. Biol. Appl. Biosci., vol. 6, no. 1, pp. 1–7, 2024, doi: https://doi.org/10.36346/sarjbab.2024.v06i01.001.

R. Van den Brom, L. Moll, F. H. M. Borgsteede, D. C. K. Van Doorn, K. Lievaart-Peterson, D. P. Dercksen, and P. Vellema, "Multiple anthelmintic resistance of Haemonchus contortus, including a case of moxidectin resistance, in a Dutch sheep flock," Vet. Rec., vol. 173, no. 22, p. 552, 2013.

N. Wirtherle, T. Schnieder, and G. von Samson‐Himmelstjerna, "Prevalence of benzimidazole resistance on horse farms in Germany," Vet. Rec., vol. 154, no. 2, pp. 39–41, 2004.

M. C. Playford, A. N. Smith, S. Love, R. B. Besier, P. Kluver, and J. N. Bailey, "Prevalence and severity of anthelmintic resistance in ovine gastrointestinal nematodes in Australia (2009–2012)," Aust. Vet. J., vol. 92, no. 12, pp. 464–471, 2014.

J. H. Drudge, J. Szanto, Z. N. Wyant, and G. Elam, "Field studies on parasite control in sheep: comparison of thia-bendazole, ruelene, and phenothiazine," 1964.

M. C. Scheuerle, M. Mahling, and K. Pfister, "Anthelminthic resistance of Haemonchus contortus in small ruminants in Switzerland and Southern Germany," Wien. Klin. Wochenschr., vol. 121, Suppl. 3, pp. 46–49, 2009.

L. C. Falzon, P. I. Menzies, K. P. Shakya, et al., "Anthelmintic resistance in sheep flocks in Ontario, Canada," Vet. Parasitol., vol. 193, no. 1–3, pp. 150–162, 2013.

M. Lyndal-Murphy, W. K. Ehrlich, and D. G. Mayer, "Anthelmintic resistance in ovine gastrointestinal nematodes in inland Southern Queensland," Aust. Vet. J., vol. 92, no. 11, pp. 415–420, 2014.

A. E. Mederos, Z. Ramos, and G. E. Banchero, "First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay," Parasites Vectors, vol. 7, no. 1, p. 598, 2014.

E. Dauparaitė, T. Kupčinskas, G. von Samson-Himmelstjerna, and S. Petkevičius, "Anthelmintic resistance of horse strongyle nematodes to ivermectin and pyrantel in Lithuania," Acta Vet. Scand., vol. 63, no. 1, p. 5, 2021.

M. Schenone, V. Dančík, B. K. Wagner, and P. A. Clemons, "Target identification and mechanism of action in chemical biology and drug discovery," Nat. Chem. Biol., vol. 9, no. 4, pp. 232–240, 2013.

R. C. Mohs and N. H. Greig, "Drug discovery and development: Role of basic biological research," Alzheimer’s Dement. Transl. Res. Clin. Interv., vol. 3, no. 4, pp. 651–657, 2017.

L. Rathor, "Medicinal plants: A rich source of bioactive molecules used in drug development," in Evidence Based Validation of Traditional Medicines: A Comprehensive Approach, pp. 195–209, 2021.

P. D. Leeson and B. Springthorpe, "The influence of drug-like concepts on decision-making in medicinal chemistry," Nat. Rev. Drug Discov., vol. 6, no. 11, pp. 881–890, 2007.

R. T. Correia, K. C. Borges, M. F. Medeiros, and M. I. Genovese, "Bioactive compounds and phenolic-linked functionality of powdered tropical fruit residues," Food Sci. Technol. Int., vol. 18, no. 6, pp. 539–547, 2012.

J. M. Carbonell‐Capella, M. Buniowska, F. J. Barba, M. J. Esteve, and A. Frígola, "Analytical methods for determining bioavailability and bioaccessibility of bioactive compounds from fruits and vegetables: A review," Compr. Rev. Food Sci. Food Saf., vol. 13, no. 2, pp. 155–171, 2014.

M. M. A. N. Ranjha, B. Shafique, L. Wang, S. Irfan, M. N. Safdar, M. A. Murtaza, ... and H. R. Nadeem, "A comprehensive review on phytochemistry, bioactivity and medicinal value of bioactive compounds of pomegranate (Punica granatum)," Adv. Tradit. Med., vol. 23, no. 1, pp. 37–57, 2023.

M. Bernela, M. Seth, N. Kaur, S. Sharma, and P. K. Pati, "Harnessing the potential of nanobiotechnology in medicinal plants," Ind. Crops Prod., vol. 194, p. 116266, 2023.

G. Mustafa, R. Arif, A. Atta, S. Sharif, and A. Jamil, "Bioactive compounds from medicinal plants and their importance in drug discovery in Pakistan," Matrix Sci. Pharma, vol. 1, no. 1, pp. 17–26, 2017.

S. Y. Pan, S. F. Zhou, S. H. Gao, Z. L. Yu, S. F. Zhang, M. K. Tang, ... and K. M. Ko, "New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics," Evid. Based Complement. Alternat. Med., vol. 2013, p. 627375, 2013.

M. Riaz, R. Khalid, M. Afzal, F. Anjum, H. Fatima, S. Zia, ... and M. A. Aslam, "Phytobioactive compounds as therapeutic agents for human diseases: A review," Food Sci. Nutr., vol. 11, no. 6, pp. 2500–2529, 2023.

World Health Organization, WHO Traditional Medicine Strategy: 2014–2023. Geneva: WHO, 2013.

T. Singh, V. K. Pandey, K. K. Dash, S. Zanwar, and R. Singh, "Natural bio-colorant and pigments: Sources and applications in food processing," J. Agric. Food Res., vol. 12, p. 100628, 2023.

H. E. Khoo, A. Azlan, S. T. Tang, and S. M. Lim, "Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits," Food Nutr. Res., vol. 61, no. 1, p. 1361779, 2017.

S. Dey and B. H. Nagababu, "Applications of food color and bio-preservatives in the food and its effect on the human health," Food Chem. Adv., vol. 1, p. 100019, 2022.

T. Tufail, H. Bader Ul Ain, S. Noreen, A. Ikram, M. T. Arshad, and M. A. Abdullahi, "Nutritional benefits of lycopene and beta‐carotene: A comprehensive overview," Food Sci. Nutr., vol. 12, no. 11, pp. 8715–8741, 2024.

P. Karak, "Biological activities of flavonoids: An overview," Int. J. Pharm. Sci. Res., vol. 10, no. 4, pp. 1567–1574, 2019.

A. N. Panche, A. D. Diwan, and S. R. Chandra, "Flavonoids: An overview," J. Nutr. Sci., vol. 5, p. e47, 2016.

J. Sharifi-Rad, C. Quispe, M. Imran, A. Rauf, M. Nadeem, T. A. Gondal, ... and D. Calina, "Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits," Oxid. Med. Cell. Longev., vol. 2021, p. 3268136, 2021.

H. Lefevere, L. Bauters, and G. Gheysen, "Salicylic acid biosynthesis in plants," Front. Plant Sci., vol. 11, p. 338, 2020.

M. Zhang, J. Yang, Z. Cai, Y. Feng, Y. Wang, D. Zhang, and X. Pan, "Detection of engineered nanoparticles in aquatic environments: current status and challenges in enrichment, separation, and analysis," Environ. Sci. Nano, vol. 6, no. 3, pp. 709–735, 2019.

A. Altemimi, N. Lakhssassi, A. Baharlouei, D. G. Watson, and D. A. Lightfoot, "Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts," Plants, vol. 6, no. 4, p. 42, 2017.

W. P. Jones and A. D. Kinghorn, "Extraction of plant secondary metabolites," in Natural Products Isolation, S. D. Sarker and L. Nahar, Eds., Methods in Molecular Biology, vol. 864, pp. 341–366, Humana Press, Totowa, NJ, USA, 2012.

G. Vinci, L. Maddaloni, S. A. Prencipe, E. Orlandini, and M. Sambucci, "Simple and reliable eco‐extraction of bioactive compounds from dark chocolate by Deep Eutectic Solvents. A sustainable study," Int. J. Food Sci. Technol., vol. 58, no. 7, pp. 4051–4065, 2023.

P. Ganesan, P. Arulselvan, and D. K. Choi, "Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus–current status," Int. J. Nanomed., pp. 1097–1111, 2017.

E. L. Gibson, J. Wardle, and C. J. Watts, "Fruit and vegetable consumption, nutritional knowledge and beliefs in mothers and children," Appetite, vol. 31, no. 2, pp. 205–228, 1998.

E. Meagher and C. Thomson, "Vitamin and mineral therapy," in Medical Nutrition and Disease, 2nd ed., G. Morrison and L. Hark, Eds., Malden, MA, USA: Blackwell Science Inc., p. 3358, 1999.

M. Saxena, J. Saxena, R. Nema, D. Singh, and A. Gupta, "Phytochemistry of medicinal plants," J. Pharmacogn. Phytochem., vol. 1, no. 6, 2013.

M. F. de Jesus Raposo, R. M. S. C. de Morais, and A. M. M. B. de Morais, "Health applications of bioactive compounds from marine microalgae," Life Sci., vol. 93, no. 15, pp. 479–486, 2013.

H. A. Salman, F. K. Hussein, and S. J. Abdulrahman, "A comparison of glutathione and malondialdehyde concentrations in athletes engaged in certain sports," Thamar Univ. J. Nat. Appl. Sci., vol. 9, no. 1, pp. 39–42, 2024.

S. Martillanes, J. Rocha-Pimienta, M. Cabrera-Bañegil, D. Martín-Vertedor, and J. Delgado-Adámez, "Application of phenolic compounds for food preservation: Food additive and active packaging," in Phenolic Compounds—Biological Activity, IntechOpen, 2017.

P. Ganesan, P. Arulselvan, and D. K. Choi, "Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus–current status," Int. J. Nanomed., pp. 1097–1111, 2017.