EFFECTS OF GINGER (ZINGIBER OFFICINALE) EXTRACT ON MALE SEXUAL MATURATION, HORMONAL PROFILE, REPRODUCTIVE ORGAN WEIGHTS, AND SPERM PARAMETERS IN PREPUBERTAL MICE
Downloads
Objective: To investigate the impact of graded doses of ginger extract on male sexual maturation, focusing on hormonal profiles, reproductive organ weights, and sperm characteristics in prepubertal mice. Method: Male mice (21–28 days old) were randomly assigned to four groups receiving 0 (control), 100, 200, or 400 mg/kg ginger extract orally for 28 days. Serum testosterone, luteinizing hormone (LH), and prolactin (PRL) were measured, and reproductive organ weights and sperm parameters were evaluated. Results: Ginger supplementation significantly increased testosterone, LH, and PRL in a dose dependent manner. Reproductive organ weights (testes, epididymis, prostate) and sperm quality indices (count, motility, viability) also improved significantly in treated groups compared with controls. Novelty: Ginger extract significantly enhances male reproductive development and function in mice, likely through endocrine stimulation and improved sperm physiology, supporting its potential use as a natural reproductive enhancer
M. Gholami Ahangaran, M. Karimi Dehkordi, A. Akbari Javar, M. Haj Salehi, and M. Ostadpoor, “A systematic review on the effect of ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans,” Vet. Med. Sci., vol. 7, no. 6, pp. 1831–1848, 2021.
M. R. Safarinejad et al., “The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double blind randomized clinical trial,” Andrologia, vol. 48, no. 8, p. e12872, 2016.
A. K. Shanoon, “Effects of Zingiber officinale powder on semen characteristics and blood serum sex hormones in broiler breeder males,” Int. J. Poult. Sci., vol. 10, no. 9, pp. 863–866, 2011.
M. S. Alessia, A. A. Shalaby, H. A. Alkarim, N. A. Ibrahim, A. B. M. Hossain, and G. Stam, “Influence of ginger (Zingiber officinale) on sperm parameters, spermatogenesis and sexual hormones of male mice,” J. Adv. Biol., vol. 8, no. 2, pp. 1607–1611, 2015.
“Zingiber officinale dietary supplementation improves reproductive performance and sperm parameters in male albino rats,” Beni Suef Univ. J. Basic Appl. Sci., vol. 14, pp. 1–10, 2025.
“Zingiber officinale roots improve reproductive aspects in male Japanese quails,” Poult. Sci. J., vol. 41, no. 1, pp. 161–174, 2023.
P. O. Ukoha et al., “Effect of ginger (Zingiber officinale) on semen quality: A systematic review of >35 studies,” Andrologia, vol. 51, no. 6, p. e13213, 2019.
A. A. Al Meshari et al., “Antioxidant and androgenic effects of dietary ginger on reproductive function of male diabetic rats,” Pak. J. Pharm. Sci., vol. 26, no. 3, pp. 445–451, 2013.
A. A. Al Meshari et al., “Safety and efficacy of Zingiber officinale roots on fertility of male diabetic rats,” Int. J. Food Sci. Nutr., vol. 61, no. 7, pp. 736–741, 2010.
“Combined ginger and cinnamon improves reproductive parameters and hormones in diabetic rats,” Hum. Fertil. (Camb)., vol. 17, no. 4, pp. 217–225, 2014.
“Effects of ginger and turmeric rhizome supplementation on reproduction in hypertensive male rats,” J. Ethnopharmacol., vol. 210, pp. 29–36, 2018.
A. O. Morakinyo et al., “Ginger rhizome extract improves reproductive function and oxidative stress markers in male rats,” Afr. J. Biomed. Res., vol. 11, no. 3, pp. 329–334, 2024.
C. O. Enebeli et al., “Ginger rhizome derivatives enhance sperm quality and hormonal balance in male rats,” Reprod. Toxicol., vol. 91, pp. 34–43, 2024.
H. Riaz et al., “Effects of ginger (Zingiber officinale) on reproductive hormones and sperm parameters: A comprehensive study,” Androl. Endocrinol. Disord., vol. 3, no. 2, pp. 77–85, 2015.
V. O. Ojugbeli et al., “Ginger derived compounds increase testosterone, sperm count and quality in rodent models,” Mol. Reprod. Dev., vol. 92, no. 1, p. e2487, 2025.
Copyright (c) 2026 Mahdi H. Hammadi
This work is licensed under a Creative Commons Attribution 4.0 International License.
