DETECTION OF CTX-M AND SHV GENES IN EXTENDED SPECTRUM BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA ISOLATED FROM WOUNDS AND BURNS AT AL-DIWANIYAH HOSPITALS
Downloads
Objective: To investigate the impact of graded doses of ginger extract on male sexual maturation, focusing on hormonal profiles, reproductive organ weights, and sperm characteristics in prepubertal mice. Method: Male mice (21–28 days old) were randomly assigned to four groups receiving 0 (control), 100, 200, or 400 mg/kg ginger extract orally for 28 days. Serum testosterone, luteinizing hormone (LH), and prolactin (PRL) were measured, and reproductive organ weights and sperm parameters were evaluated. Results: Ginger supplementation significantly increased testosterone, LH, and PRL in a dose dependent manner. Reproductive organ weights (testes, epididymis, prostate) and sperm quality indices (count, motility, viability) also improved significantly in treated groups compared with controls. Novelty: Ginger extract significantly enhances male reproductive development and function in mice, likely through endocrine stimulation and improved sperm physiology, supporting its potential use as a natural reproductive enhancer
M. E. ; C. M. A. ; C. K. K. ; G. N. S. 4. Jeschke M. G.; van Baar and S. Logsetty, “4. Jeschke, M. G.; van Baar, M. E.; Choudhry, M. A.; Chung, K. K.; Gibran, N. S. and Logsetty, S.,” M., p. N/A, 2020.
W. H. 3. Organization, “3. Organization, W. H.,” W., p. N/A, 2020.
N. A. Che Soh, H. S. Rapi, N. S. Mohd Azam, R. K. Santhanam, S. Assaw, and M. N. Haron, “Acute Wound Healing Potential of Marine Worm, Diopatra claparedii Grube, 1878 Aqueous Extract on Sprague Dawley Rats,” Evidence-Based Complementary and Alternative Medicine, 2020.
B. Gülhan, S. Kanık Yüksek, M. Hayran, A. Özkaya Parlakay, D. Güney, and G. Akın Kağızmanlı, “Infections in pediatric burn patients: an analysis of one hundred eighty-one patients,” Surg. Infect. (Larchmt)., vol. 21, no. 4, pp. 357–362, 2020.
& I. C. S. 2. Kumar K. M., “2. Kumar, K. M., & Illamani, C. S.,” K., p. N/A, 2021.
H. D. A. S. J. M. & S. da C. T. P. 6. Impey R. E., “6. Impey, R. E., Hawkins, D. A., Sutton, J. M., & Soares da Costa, T. P.,” R., p. N/A, 2020.
& S. E. D. 5. Abd Al-Mayali M., “5. Abd Al-Mayali, M., & Salman, E. D.,” Al-Mayali, p. N/A, 2020.
M. J. L. A. E. A. B. G. F. B. J. S. 7. Jawetz E. and S. A. Morse, “7. Jawetz, E., Melnik, J.L., Adelberg, E.A., Brook, G.F., Butel, J.S. and Morse, S.A.,” E., p. N/A, 2019.
M. R. Saleh, “The Role of Marketing Control in Enhancing the Dimensions of Customer Satisfaction,” Tikrit Journal of Administrative and Economic Sciences, vol. 16, no. 5, 2020.
H. A. D. Al-Kazrage, “Inhibition of Virulence Factors in Pseudomonas aeruginosa Isolated from Clinical Samples Using Galardin Loaded AgPEG Nanocomposite,” 2022.
E. N. Naji, A. A. Ali, and B. F. Hamzah, “The Bactericidal Effect of CO2 Laser on Pseudomonas aeruginosa Isolated from Wound and Burn Infections, In-Vitro,” Baghdad Science Journal, vol. 12, no. 3, 2015.
Z. T. A. 32. Hasoon, “32. Hasoon, Z. T. A.,” Z., p. N/A, 2021.
33. Younis R M. and F. R. M., “33. Younis R. M. and Faisal R. M.,” R., p. N/A, 2024.
G. Z. T. G. G. G. T. 31. Araya S. and A. E. Negesso, “31. Araya, S., Gebreyohannes, Z., Tadlo, G., Gessew, G. T., and Negesso, A. E.,” S., p. N/A, 2023.
D. P. Nichols et al., “Effects of azithromycin in Pseudomonas aeruginosa burn wound infection,” Journal of Surgical Research, vol. 183, no. 2, pp. 767–776, 2013.
S. Parsnjothi and D. R., “Screening for multidrug resistance Pseudomonas aeruginosa bacteria in a hospitalized patient in Hosur, Krishnagiri,” International Journal of Pharma Biosci, vol. 1, no. 3, pp. 9–281, 2010.
D. Church, S. Elsayed, O. Reid, B. Winston, and R. Lindsay, “Burn Wound Infections,” Clin. Microbiol. Rev., vol. 19, no. 2, pp. 403–434, 2006.
S. S. AL-Salihi, B. H. Hameed, and B. H. Hameed, “Antibiosisresistant of Pseudomonas aeruginosa isolated from different clinical specimens,” Kirkuk University Journal for Scientific Studies, vol. 9, no. 2, 2014.
L. E. D. O. N. J. L. & A. B. Rizkalla N., “Elucidating the factors affecting entrepreneurs’ intention to adopt social media in their business: A perspective from Indonesia,” 2023.
S. K. Shehab and E. H. Jassim, “Impact of Mint oil and Colistin antibiotic on pilB gene of clinical Pseudomonas aeruginosa Isolates from Baghdad, Iraq,” Iraqi Journal of Biotechnology, vol. 18, no. 3, 2019.
V. 27. Novik G.; Savich and E. Kiseleva, “27. Novik, G.; Savich, V. and Kiseleva, E.,” G.;, p. N/A, 2015.
B. G. G. M. K. S. S. & R. P. W. 30. Tripathi P., “30. Tripathi, P., Banerjee, G., Gupta, M. K., Saxena, S., & Ramteke, P. W.,” P., p. N/A, 2013.
N. Bose and S. D. Moore, “Variable Region Sequences Influence 16S rRNA Performance,” in Microbiologyspectrum, vol. 11, no. 3, 2023, p. e0125223. doi: 10.1128/spectrum.01252-23.
K. S. S. Q. 10. Ali F. and S. Ahmed, “10. Ali, F., Kamal, S., Shakeela, Q., and Ahmed, S.,” F., p. N/A, 2021.
A. K. Idan, “Molecular Detection of Some Antimicrobial Resistance Genes in Pseudomonas aeruginosa Clinical and Hospital Environment,” 2021.
O. E. Okobi, E. O. Evbayekha, H. O. Shittu, I. E. Arinze, and et al., “Antibiogram at a rural hospital against the background of COVID-19: a five-year retrospective review,” Cureus, vol. 14, no. 7, 2022.
M. S. Walters, J. E. Grass, S. N. Bulens, E. B. Hancock, and et al., “Carbapenem-resistant Pseudomonas aeruginosa at US emerging infections program sites, 2015,” Emerg. Infect. Dis., vol. 25, no. 7, p. 1281, 2019.
I. Z. A. L. 35. Al-Hashimy S. K. and M. A. Abdulrazaq, “35. Al-Hashimy, S. K., Ismaeel, Z. A. L., and Abdulrazaq, M. A.,” S., p. N/A, 2021.
& K. H. 1. Jafari-Sales A., “1. Jafari-Sales, A., & Khaneshpour, H.,” A., p. N/A, 2020.
F. Ali, Q. Shakeela, B. Uzma, A. Bibi, and et al., “Antimicrobial resistance pattern and phenotypic detection of ESBL- and MBL-producing Pseudomonas aeruginosa isolated from indoor patients suffering ear discharge,” Kuwait Journal of Science, vol. 49, no. 2, 2022.
M. G. A. T. S. A. 34. Shah S. and S. Bano, “34. Shah, S., Mako, G. A., Tunio, S. A., and Bano, S.,” S., p. N/A, 2024.
H. D. R. N. R. M. J. T. S. for E. M.-R. P. aeruginosa. I. D. Ther. 2022;11 26. Kunz Coyne AJ El Ghali A, “26. Kunz Coyne AJ, El Ghali A, Holger D, Rebold N, Rybak MJ. Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa. Infect Dis Ther. 2022;11,” Coyne, p. N/A, 2AD.
K. S. S. Q. 10. Ali F. and S. Ahmed, “10. Ali, F., Kamal, S., Shakeela, Q., and Ahmed, S.,” F., p. N/A, 2021.
H. A. J. G. L. B. P. Z. L. N. J. P. C. S. abd M. T. F. 28. Hall C. W., “28. Hall, C. W., Hinz, A. J., Gagnon, L. B. P., Zhang, L., Nadeau, J. P., Copeland, S., abd Mah, T. F.,” C (Basel)., p. N/A, 2018.
C. W. C. & V. H. 29. Arzanlou M., “29. Arzanlou, M., Chai, W. C., & Venter, H.,” M., p. N/A, 2017.
A. Peymani, T. N. Farivar, R. Najafipour, and S. Mansouri, “High prevalence of plasmid-mediated quinolone resistance determinants in Enterobacter cloacae isolated from hospitals of the Qazvin, Alborz, and Tehran provinces, Iran,” Revistada Sociedade Brasileira de Medicina Tropical, vol. 49, pp. 286–291, 2016.
M. I. Khan, “Frequency and antimicrobial susceptibility pattern of Pseudomonas aeruginosa in human pus samples at holy family hospital Rawalpindi,” J. Microbiol. Biotechnol., vol. 6, no. 1, p. 189, 2021.
S. Zeraatkar et al., “Antibacterial activity of Mangifera indica seed extracts combined with common antibiotics against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates,” Biosci J, vol. 39, 2023, doi: 10.14393/BJ-v39n0a2023-66760.
N. Othman, M. Babakir-Mina, C. K. Noori, and P. Y. Rashid, “Pseudomonas aeruginosa infection in burn patients in Sulaimaniyah, Iraq: risk factors and antibiotic resistance rates,” The Journal of Infection in Developing Countries, vol. 8, no. 11, pp. 1498–1502, 2014.
CLSI, “Performance standards for antimicrobial susceptibility testing,” 2022.
M. Komijani, K. Shahin, M. Barazandeh, and M. Sajadi, “Prevalence of extended-spectrum β-lactamases genes in clinical isolates of Pseudomonas aeruginosa,” Medical Laboratory Journal, vol. 10, no. 12, pp. 34–41, 2018.
A.-E. B. W. 9. Majeed Issa O. and M. Ayad Abbas, “9. Majeed Issa, O., Abdul-Elah Bakir, W. and Ayad Abbas, M.,” Issa, p. N/A, 2022.
Copyright (c) 2026 .Nada Ahmed Fairouz

This work is licensed under a Creative Commons Attribution 4.0 International License.














