Estimated Glycation End Products and Oxidative Status in Renal Failure Patients

Salam Khalid Mutlag; Mohanad Hammo Mukhlif1

doi:10.61796/jmgcb.v1i2.369

Authors

Salam Khalid Mutlag
mohaned.bio@gmail.com
a:1:{s:5:"en_US";s:60:"Ministry of Education, Directorate of Kirkuk Education, Iraq";}
Mohanad Hammo Mukhlif1 Ministry of Education, Directorate of Kirkuk Education, Iraq

Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology

Articles

March 14, 2024

Downloads

View Article

Abstract
How to Cite
Metrics
References
License

The present study conducted to assess the Glycation end products and oxidative status of in patients with renal failure. 100 patients that have had CKD for less than 2 years have been diagnosed by a doctor. A control group of 40 stable individuals was selected. From October 2021 to February 2022, patients were confirmed to be sick with chronic renal disease at Azadi Teaching Hospital and Al-Jumhuri Hospital. ‎the results showed that the largest age group of patients was > 60 years with percent (39%). Body Mass Index (BMI) of patients was 18.5-24.9 kg with percent (52%). Residential Area of patients was urban with percent (83%). Smoking Status of patients was non-smoking with percent (68%). The current outcomes demonstrated a reduction in the concentration of total protein that is significant (P<0.05), albumin and globulin in patients compare with healthy volunteers. On the other hand, the results show a significant (P<0.05) elevated in levels of carbonyl and amino group, while decreased in thiol levels in patients compare with healthy volunteers. Otherwise, the Glycation level shows significant (P<0.05) elevated in in patients compare with healthy volunteers. Its concluded that the CKD lead to elevated Glycation level and changes in oxidative status.

Mutlag, S. K., & Mukhlif1, M. H. (2024). Estimated Glycation End Products and Oxidative Status in Renal Failure Patients. Journal of Medical Genetics and Clinical Biology, 1(2), 103–110. https://doi.org/10.61796/jmgcb.v1i2.369

Download Citation

2. Saran R, Robinson B, Abbott KC. (2020). US Renal Data System 2019 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 75: A6–A7.

Shawkat E. A., Sahib J. Abdulrahman and Basheer A. B. (2023). Assessment the Role of Erythropoietin, Hepcidin and Albumin in Patients with Chronic Kidney Disease in Kirkuk-Iraq., Kirkuk Journal of Science, 18(3): 7-12.

Morshed S. M., Abed A. A, Sadiq L. (2022). Effect of exposure to cement dust of residents in vicinity of kirkuk cement factory on kidney parameters. Kirkuk University Journal-Scientific Studies, 17(4): 1-5.

Zhang, L. (2012). Prevalence of chronic kidney disease in China: a cross sectional survey. Lancet 379, 815-22.

Arora, P. (2013). Prevalence estimates of chronic kidney disease in Canada:results of a nationally representative survey. CMAJ 185, E417-423.

White, S.L., Polkinghorne, K.R., Atkins, R.C. & Chadban, S.J. (2010). Comparison of the prevalence and mortality risk of CKD in Australia using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. Am J Kidney Dis 55, 660-70.

Girndt, M., Trocchi, P., Scheidt-Nave, C., Markau, S. & Stang, A. (2016). The Prevalence of Renal Failure. Results from the German Health Interview and Examination Survey for Adults, 2008-2011 (DEGS1). Dtsch Arztebl Int 113, 85-91.

Fraser, S.D. (2015). Exploration of chronic kidney disease prevalence estimates using new measures of kidney function in the health survey for England. PLoS One 10, e0118676.

Zhang, J., Wang, Z., Healy, H. G., Venuthurupalli, S. K., Tan, K. S., Fassett, R. G. & Hoy, W. E. (2016). An overview of patients with chronic kidney disease, and their outcomes, in the Australian CKD.QLD Registry (2011-2016).

Nazar A Naji, Sabah H Khorsheed, and Intisar F Mustafa. (2016). Study the activity of tryptase and beta 2-microglobulin levels in the sera of patients with chronic renal failure and rheumatoid arthritis. Kirkuk University Journal-Scientific Studies, 11(1): 1-6.

Assadi F (2013) Strategies to reduce the incidence of chronic kidney disease in children: Time for action. J Nephrol 26(1): 41-47.

Habeeb A.F.S.A. (1972). Reaction of protein sulfhydryl groups with Ellman's reagent. Methods in Enzymology 25: 57-464.

Marcello P., Monika K., Dominik H. Milica B., Claus S., Nevena J., Andres K., Jose M. M., Marine B., Andrew M. H. (2022). Spatiotemporal organisation of protein processing in the kidney. Nature Communications. 13(5732): 1-6.

Tong C., Xiaoyu W., Yong H., Jianbing H., Haofei H., Lirong H. (2023). The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease. BMC Nephrology. 24(57): 1-5.

Rutkowski B, Szolkiewicz M, Korczynsk J. (2003). The role of lipogenesis in the development of uremic hyperlipidemia. Am J Kidney Dis. 41:84-88.

Nicholson J. P., M. R. Wolmarans, and G. R. Park, (2000). The role of albumin in critical illness,” British Journal of Anaesthesia, 85(4): 599–610.

Fanali G., A. di Masi, V. Trezza, M. Marino, M. Fasano, and P. Ascenzi, (2012). Human serum albumin: from bench to bedside,” Molecular Aspects of Medicine, 33(3): 209–290.

Arques S. and P. Ambrosi, (2011). Human serum albumin in the clinical syndrome of heart failure,” Journal of Cardiac Failure, 17(6): 451–458.

Franch-Arcas G., (2001). The meaning of hypoalbuminaemia in clinical practice,” Clinical Nutrition, 20(3): 265–269.

Iwasaki T., Togashi Y.; and Terauchi Y. (2008). “Significant association of serum albumin with severity of retinopathy and neuropathy, in addition to that of nephropathy, in Japanese type 2 diabetic patients,” Endocrine Journal, 55(2): 311–316.

Oh S. W.; Kim S. and Na K. Y. (2012). “Clinical implications of pathologic diagnosis and classification for diabetic nephropathy,” Diabetes Research and Clinical Practice, 97(3): 418–424.

Li L., Zhang X. and Li Z. (2017). Renal pathological implications in type 2 diabetes mellitus ;atients with renal involvement,”Journal of Diabetes and its Complications, 31(1): 114– 121.

Fiorentino M. and Bolignano D. and Tesar V. (2017). Renal biopsy in patients with diabetes: a pooled meta-analysis of 48 studies,” Nephrology Dialysis Transplantation, (1) 97– 110.

Dursun E, Ozben T, Su¨leymanlar G, Dursun B, Yakupoglu G. (2002). Effect of hemodialysis on the oxidative stress and antioxidants. Clin Chem Lab Med. 40: 1009–13

Barreiro E. (2016). Role of protein carbonylation in skeletal muscle mass loss associated with chronic conditions. Proteomes. 4(2):18.

Kathrin U., Ursula J. (2019). The role of thiols in antioxidant systems. Free Radic Biol Med.140: 14–27.

Turell L, Radi R, Alvarez B: The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med 2013;65:244-253.

Qian, J.; Fang, J.; Zhu, Q.; Ma, S.; Wang, W.; Zheng, Y.; Hao, G.; Deng, B.; Zhao, X.; Ding, F. Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury. Kidney Blood Press. Res. 2015, 40, 623–629.

Ayar, G.; Sahin, S.; Yazici, M.U.; Neselioglu, S.; Erel, O.; Bayrakci, U.S. Effects of Hemodialysis on Thiol-Disulphide Homeostasis in Critically Ill Pediatric Patients with Acute Kidney Injury. BioMed Res. Int. 2018, 2018, 1898671.

Sirangelo I., Clara I. (2021). Understanding the Role of Protein Glycation in the Amyloid Aggregation Process. Int. J. Mol. Sci. 22(12): 6609

Fangxu S., Suttipong S., Haopeng X., Ronghu W. (2019). Comprehensive Analysis of Protein Glycation Reveals Its Potential Impacts on Protein Degradation and Gene Expression in Human Cells. J Am Soc Mass Spectrom. 30(12): 2480–2490.

Katarzyna Z., Marta T., Patrycja T., Maciej T. (2023). A Role for Advanced Glycation End Products in Molecular Ageing. Int. J. Mol. Sci. 24(12): 9881.

Jingyang C., Dong Y., Kefei D. (2023). Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions. Cardiovascular Diabetology 22(146): 1-8.