PATHOPHYSIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AND DRUG RESISTANCE

Ataa Elias Karum; Soha Jassim Mohammed; Sanaa Adnan Abdul Hussein; Israa Saleh Ahmed; Marwa Muhammad Odeh

doi:10.61796/jmgcb.v1i4.407

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Ataa Elias Karum
ataa@gmail.com
Department of biology, College of Science, University of Al Mosul
Soha Jassim Mohammed Department of biology, College of Science, University of Al Anbar
Sanaa Adnan Abdul Hussein Department of biology, College of Science for woman, University of Babylon
Israa Saleh Ahmed Department of biology, College of Science, University of Al Mosul
Marwa Muhammad Odeh Department of biology, College of Science, University of Basrah

Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology

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April 30, 2024

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Methicillin- resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens of community and hospital acquired bacterial infections. MRSA can lead to diverse infection such as bacteremia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital- acquired infections . As well as genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. They are also becoming increasingly multi-drug resistant and have recently developed resistance to vancomycin, which has been used successfully to treat MRSA for many years . Successful treatment remains challenging and requires the evaluation of novel antimicrobials. In Conclusion the emergence of CA-MRSA and VRSA isolates is changing the management of clinical infections potentially caused by S. aureus. Rapid methods for accurate detection of MRSA are needed to promptly identify patients and implement contact precautions as well as appropriate treatment. Molecular genotyping techniques have an important role in evaluating possible outbreaks and for understanding of the emergence and evolution of MRSA strains

Karum, A. E., Mohammed, S. J., Hussein, S. A. A., Ahmed, I. S., & Odeh, M. M. (2024). PATHOPHYSIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AND DRUG RESISTANCE. Journal of Medical Genetics and Clinical Biology, 1(4), 71–77. https://doi.org/10.61796/jmgcb.v1i4.407

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. Barber, M. (1961). Methicillin-resistant staphylococci. Journal of Clinical Pathology, 14(4), 385.

. Boundless. (2016). "Boundless Microbiology". Retrieved from [Link]

. Cunha, R. A., & Calsolari, O. (2008). Toxigenicity in Staphylococcus aureus and coagulase-negative staphylococci: epidemiological and molecular aspects. Microbiology Insights, 1, MBI-S796.

. Garza-González, E., & Dowzicky, M. J. (2013). Changes in Staphylococcus aureus susceptibility across Latin America between 2004 and 2010. Brazilian Journal of Infectious Diseases, 17(1), 13-19.

. Henson, P. M., & Johnston, R. B. (1987). Tissue injury in inflammation: Oxidants, proteinases, and cationic proteins. Journal of Clinical Investigation, 79(3), 669-674.

. Hirschmann, & Jan, V. (2007). The early history of coccidioidomycosis: 1892–1945. Clinical Infectious Diseases, 44(9), 1202-1207.

. Islam, M., Alam, M., Choudhury, M., Kobayashi, N., & Ahmed, M. (2008). Detection of minimum inhibitory concentration (MIC) of cloxacillin for selected isolates of methicillin-resistant Staphylococcus aureus (MRSA) with their antibiogram. Bangladesh Journal of Veterinary Medicine, 6(1), 121-126.

. Kateete, D. P., Kimani, C. N., Katabazi, F. A., Okeng, A., Okee, M. S., Nanteza, A.,... Najjuka, F. C. (2010). Annals of Clinical Microbiology and Antimicrobials, 9, 23.

. Mulcahy, M. E., & McLoughlin, R. M. (2016). Host–bacterial crosstalk determines Staphylococcus aureus nasal colonization. Trends in Microbiology, 24(11), 872-886.

. National Committee for Clinical Laboratory Standards, NCCLS. (2004). Performance standards for antimicrobial susceptibility testing; 14th information supplement. M100-S14, 24(1). Wayne, PA, USA: NCCLS.

. Noskin, G. (2005). Tigecycline: A new glycylcycline for treatment of serious infections. Clinical Infectious Diseases, 41(5), 303-314.

. Schnellmann, C., Gerber, V., Rossano, A., Jaquier, V., Panchaud, Y., Doherr, M. G.,... Perreten, V. (2006). Presence of new mecA and mph (c) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission. Journal of Clinical Microbiology.

. Söderquist, B. (2007). Surgical site infections in cardiac surgery: Microbiology. APMIS, 115(9), 1008-1011.

. Solouki, S., August, A., & Huang, W. (2019). Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications. Pharmacology & Therapeutics, 201, 39-50.

. Tomasz, A., Drugeon, H. B., De Lencastre, H. M., Jabes, D., McDougall, L., & Bille, J. (1989). New mechanism for methicillin resistance in Staphylococcus aureus: Clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity. Antimicrobial Agents and Chemotherapy, 33(11).

. Ubukata, K. I., Yamashita, N. A., & Konno, M. A. (1985). Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrobial Agents and Chemotherapy, 27(5), 851.

. Wallach, D., Kang, T. B., & Kovalenko, A. (2014). Concepts of tissue injury and cell death in inflammation: A historical perspective. Nature Reviews Immunology, 14(1), 51-59.

. Weiss, S. J. (1989). Tissue destruction by neutrophils. New England Journal of Medicine, 320(6), 365-376.

. Ziebuhr, W., Heilmann, C., Götz, F., Meyer, P., Wilms, K., Straube, E., & Hacker, J. (1997). Detection of the intercellular adhesion gene cluster (ica) and phase variation in Staphylococcus epidermidis blood culture strains and mucosal isolates. Infection and Immunity, 65(3), 890-897.