DETECTING THE ROLE OF QUINOA AGAINST THE TOXICITY OF HYDROGEN PEROXIDE, WHICH CAUSES DAMAGE TO TESTICULAR TISSUE, AND SOME PHYSIOLOGICAL PARAMETERS IN MALE RATS

Bayan M. Mahdi; Hiyam J. Ibrahim; Rajaa M. Ismail

doi:10.61796/jmgcb.v1i6.558

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Bayan M. Mahdi Kirkuk University, Iraq
Hiyam J. Ibrahim Kirkuk University, Iraq
Rajaa M. Ismail
rajamoussa@uokirkuk.edu.iq
Kirkuk University, Iraq

Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology

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June 8, 2024

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The current study aims to reveal the role of Quinoa seeds against the toxicity of hydrogen peroxide, which causes damage to testicular tissue and some physiological parameters in male rats. In this study 32 adult male albino rats, (wt 180-260 gm with age 3-5 month) obtained from Veterinary college/ Kirkuk University. the rats were randomly divided into four groups, control (n=8), and experimental (n=24) groups. The control group just received 4ml distilled water daily. However, the experimental groups divided into three groups each included 8 male albino rat. The findings showed that the concentration of testosterone (TE), follicle stimulating hormone (FSH) and luteinizing hormone (LH) in second group show significant (P<0.05) reduced compared with control rats. While, the concentration of TE, FSH and LH in third and fourth groups show non-significant changes (P<0.05) compared with control rats. For oxidative status, that the concentration of malonedialdehyied (MDA), glutathione (GSH) and catalase in second group show significant (P<0.05) elevated compared with control rats. While, the concentration of MDA, GSH and catalase in third and fourth groups show non-significant changes (P<0.05) compared with control rats. For histological study, the cross section taken from the second group demonstrates a decrease in the number of spermatogonia and spermatocytes as well as the absence of spermatid, the sections that were obtained from the third and fourth groups display spermatogonia, spermatocytes, and spermatids in a semi-normal structure. Therefore, it is concluded from the current study that Quinoa seeds extract has antioxidant activity and enhances and improves the effectiveness of the male reproductive system.

Bayan M. Mahdi, Hiyam J. Ibrahim, & Rajaa M. Ismail. (2024). DETECTING THE ROLE OF QUINOA AGAINST THE TOXICITY OF HYDROGEN PEROXIDE, WHICH CAUSES DAMAGE TO TESTICULAR TISSUE, AND SOME PHYSIOLOGICAL PARAMETERS IN MALE RATS. Journal of Medical Genetics and Clinical Biology, 1(6), 48–57. https://doi.org/10.61796/jmgcb.v1i6.558

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Alvarez-Jubete, L., Auty, M., Arendt, E.K., & Gallagher, E. (2010). Baking properties and microstructure of pseudo-cereal flours in gluten-free bread formulations. Eur Food Res Technol 230, 437–445.

Maradini-Filho, A.M., Pirozi, M.R., Borges, J.T.S., Santana, H.M.P., Chaves, J.B.P., et al. (2017). Quinoa: Nutritional, functional and anti-nutritional aspects. Crit Rev Food Sci Nutr 57, 1618-1630.

Saeed, M.S., Saeed, A., Iqbal, M., & Adnan, M. (2020). Nutritional Benefits of Quinoa-A Review, Ind. J. Pure App. Biosci. 8(6), 624-627.

Vega-Gálvez A, Miranda M, Vergara J, Uribe E, Puente L, et al. (2010) Nutrition facts and functional potential of quinoa (Chenopodium quinoa Willd.), an ancient Andean grain: a review. J Sci Food Agric 90: 2541-2547.

Jancurová M, Minarovicova L, Dandar A (2009) Quinoa - A Review. Czech J Food Sci 27: 71-79.

Koziol MJ (1992) Chemical Composition and Nutritional Evaluation of Quinoa (Chenopodium quinoa Willd.). J Food Comp Anal 5: 35-68.

Asao M, Watanabe K (2010) Functional and Bioactive Properties of Quinoa and Amaranth. Food Sci Technol Res 16: 163-8.

Cooper R (2015) Re-discovering ancient wheat varieties as functional foods. J Tradit Complement Med 5: 138-143.

Ando, H., Chen, Y., Tang, H., Shimizu, M., Watanabe, K., & Mitsunaga, T. (2002). Food components in fractions of quinoa seed. Food Science and Technology Research, 8, 80-84.

Lindeboon, N. (2005). Studies on the characterization, biosynthesis and isolation of starch and protein from quinoa (Chenopodium quinoa Willd.). Ph.D Thesis, University of Saskatchewan, Canada, 1–135.

Konishi, Y., Hirano, S., Tsuboi, H., & Wada, M. (2004). Distribution of minerals in quinoa (Chenopodium quinoa Willd.) seeds. Bioscience, Biotechnology, and Biochemistry, 68, 231-234.

Mohyuddin, S. G., Riaz, A., Qamar, A., Ali, S. H., Hu, C., Wu, L., Yu, T., & Ju, X. H. (2019). Quinoa is beneficial to the comprehensive nutritional value of potential health. Pakistan Journal of Science, 71(2), 69-74.

Gawlik-Dziki, U., Świeca, M., Sułkowski, M., Dziki, D., Baraniak, B., & Czyż, J. (2013). Antioxidant and anticancer activities of Chenopodium quinoa leaves extracts- in vitro study. Food and Chemical Toxicology, 57, 154-160.

Deželak, M., Zarnkow, M., Becker, T., & Košir, I. J. (2014). Processing of bottom-fermented gluten-free beer-like beverages based on buckwheat and quinoa malt with chemical and sensory characterization. Journal of the Institute of Brewing, 120, 360-370.

Anonymous, (2014). The European Commission, Commission implementing regulation (EU) No 828/2014 of 30 July 2014 on the requirements for the provision of information to consumers on the absence or reduced presence of gluten in food. Off J European Union, L228, 5-8.

Bedard, K. and Krause, K.H. (2007). The Nox family of ROS- Generating NADPH oxidases "Physiology and Pathophysiology Physiol. Rev, 87 (1): 245 – 313.

Forman, H.J. and Torres, M. (2002).Reactive oxygen species and cell signaling: respiratory burst in macrophages signaling. Am. J. Respir. Care Med., 166: S 4-S8.

Meera, S.; Gupta Atyan, V.S. and Kumar, N.S.(2008). Immunomodulatory and antioxidant activity of polyhedral formulation.Intern. J. of Pharmacol., 4:287-291.

Khudaier, K.K. (2008). Effect of hydrogen peroxide on immune response (cellular and humeral) immunity of adult male rabbits.Iraq. J.of Biol.Technique.7 (2): 1-7.

Handa, S. S. (2008). An overview of extraction techniques for medicinal and aromatic plants. Extraction technologies for medicinal and aromatic plants, 1(1), 21-40.

Sahi, Merad-Boudia, H. N., M., Kachekouche, Y., and Dennouni-Medjati, N. (2019). Hematologic disorders during essential hypertension. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(2), 1575-1579.

Ahmed, K.O. and Saleh, A.H. (2021). Effects of Estrogen in Treating Myocardial Damages Caused by Ischemia in Adult Female Rats. International Journal of Drug Delivery Technology. 11(4):1474–1477.

Saleh, A.H. (2019). Potential effect of green zinc oxide nanoparticles in treatment of kidney lesions that induced by Burkholderia mallei in albino male rats Biochemical and Cellular Arch. 19: 2439–2443.

Abdul, M.R., Rahim, S.M., Saleh, A.H. (2023). Cardioprotective Activity of Costus Root Ethanol Extract in Experimentally-Induced Hypothyroidism in Female Albino Rats. HAYATI Journal of Biosciences, 30(6): 1054–1060.

Hamad, Z.M. (2016). Role of ethanolic extract of Eruca sativa seeds in testicular dysfunction mediated oxidative stress caused by cadmium chloride in male rats. PhD. Thesis. College of Veterinary Medicine /University of Baghdad.

Nowfel, A.J. and Al-Okaily, B.N. (2017). Oxidative stress: Role of Eruca sativa extract on male reproduction in rats. Adv. Anim. Vet. Sci. 5(1): 39-4.

Ismail, H. and Al-nahari, H. (2009). Therapeutic and protective role of Panax ginseng on pituitary and testicular axis in male rats treated with carbon tetrachloride .Ale J Agric Res., 54(1):1-12.

Lutz, M., & Bascuñán-Godoy, L. (2017). The Revival of Quinoa: A Crop for Health. Waisundara V, Shiomi N, editors. Superfood and Functional Food - An Overview of Their Processing and Utilization. Croatia: InTech.

Tang, Y., Zhang, B., Li, X., Chen, P. X., Zhang, H., Liu, R., & Tsao, R. (2016). Bound phenolics of quinoa seeds released by acid, alkaline, and enzymatic treatments and their antioxidant and α-glucosidase and pancreatic lipase inhibitory effects. Journal of Agricultural and Food Chemistry, 64, 1712-1719.

Multari, S., Marsol-Vall, A., Keskitalo, M., Yang, B., & Suomela, J. P. (2018). Effects of different drying temperatures on the content of phenolic compounds and carotenoids in quinoa seeds (Chenopodium quinoa) from Finland. Journal of Food Composition and Analysis, 72, 75-82.

Wahba, H. M. A., Mahmoud, M. H., & Mehiry, H. F. E. (2019). Effect of quinoa seeds against Cisplatin toxicity in female rats. Journal of Advanced Pharmacy Education & Research, 9(3), 46-52.

Livingstone, C. and Davis,J. (2007). Review: Targeting therapeutics against glutathione depletion in diabetes and its complications. The British Journal of Diabetes and Vascular Disease. 7(6):258-265.

Khudaier, K. K.; Abdullah, B.N. and Muzaien, K.A.(2001). The protective effect of aqueous extract of parsley (Petroselinum Sativum) on experimentally-induced oxidative stress in rats.The Iraqi. J.Vet.Med. 25(1):153-172.

Lee, T.; Kim, S.; Yu, S.; Kim, S.; Park, D.; Moon, H. Dho, S.; Kwon K, Kwon H, Han Y, Jeong S, Kang S, Shin H, Lee K, Rhee S, and Yu D. (2003). Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood. 101 (12): 5033- 5038

Pasko, P., Barton, H., Zagrodzki, P., Izewska, A., Krosniak, M., Gawlik, M., Gawlik, M., & Gorinstein, S. (2010). Effect of diet supplemented with quinoa seeds on oxidative status in plasma and selected tissues of high fructose-fed rats. Plant Foods for Human Nutrition, 65(2), 146- 151.

Halliwell, B.; Gutteridge, J.(1995). The definition and measurement of antioxidants in biological systems. Free Radic. Biol. Med. 18, 125-126.

Ashok A, Gurpriya V., Chloe S., Stefan S. (2014). Effect of Oxidative Stress on Male Reproduction. The World Journal of Men s Health 32(1):1-17.

Graf, B. L., Rojas-Silva, P., Rojo, L. E., Delatorre-Herrera, J., Baldeon, M. E., & Raskin, I. (2015). Innovations in health value and functional food development of quinoa (Chenopodium quinoa Willd.). Comprehensive Reviews in Food Science and Food Safety, 14 (4), 431-445.