ELEVATE SOME TYPES OF ADIPOKINES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS)
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The current work aimed to estimate some types of Adipokines (Leptin, adiponectin and the resistin) in PCOS women. The participants belong to both PCOS women and healthy women were selected and examined in Azadi teaching hospital at September 2021 to February 2022. 80 patients with 30 controls were used in this study. The current outcomes show the concentration of Leptin in PCOS patients, where concentration of Leptin demonstrated significant (P <0.05) elevate in PCOS women compared with healthy women. Adiponectin concentration in PCOS women indicated significant (P <0.05) reduce compared with healthy women. Resistin concentration in PCOS women indicated significant (P <0.05) raise compared with healthy women. So, based on this findings, PCOS lead to significant (P <0.05) differences in concentration of some types of Adipokines.
. Deans, R. Polycystic ovary syndrome in adolescence. Med. Sci. 2019, 7, 101
. Witchel, S.F.; E Oberfield, S.; Peña, A.S. Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls. J. Endocr. Soc. 2019, 3, 1545–1573.
. Polycystic Ovary Syndrome. Available online: https:// www.womenshealth.gov/a-z-topics/polycystic-ovary-syndrome (accessed on 22 September 2021).
. Dunaif A. "Insulin resistance and the Polycystic Ovary Syndrome .mechanism and implications. Insulin action and hyperandrogenism : clinical , histological and biochemical findings" . J Clin Endocrinol Metab 21; 1997: 1440 -1445.
. Barber TM, McCarthy MI, Wass JAH and Franks S " Obesity and Polycystic Ovary Syndrome. Clin Endocrinol. 65(2); 2006:137-145.
. Dunaif A ,Green G, Phelps RG, Lebwohl M, Futter Weitw and Lewyl. "Acanthosis nigricans ,insulin action and hyperandrogenism: Clinical, histological and biochemical finding" .J Clin Endocrinol Metab, 73; 1991: 590 – 595.
. Dimitriadis, G. K., Kyrou, I and Randeva, H. S. 2016. Polycystic ovary syndrome as a proinflammatory state: the role of adipokines. Curr Pharm Des, 22: 5535-5546.
. Wang. L.,Qing, H., Baker, P.N., Zhen, Q., Zeng, Q., Shi, R.,Tong, C. and Ger, Q. 2017 .Altered circulating inflammatory cytokines are associated with anovulatory polycystic ovary syndrome (PCOS) women resistant to clomiphene citrate treatment. Med Sci Monet, 23: 1083-1089.
. Ebejer, K. and Calleja, A. 2013. The role of cytokines in polycystic ovarian syndrome. Gynecology Endocrinol, 29: 536-540.
. Vegiopoulos, A.; Rohm, M.; Herzig, S. Adipose tissue: Between the extremes. EMBO J. 2017, 36, 1999–2017.
. Emerging Risk Factors Collaboration; Kaptoge, S.; Di Angelantonio, E.; Pennells, L.; Wood, A.M.; White, I.R.; Gao, P.; Walker, M.; Thompson, A.; Sarwar, N.; et al. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N. Engl. J. Med. 2012, 367, 1310–1320
. Schnabel, R.B.; Yin, X.; Larson, M.; Yamamoto, J.F.; Fontes, J.D.; Kathiresan, S.; Rong, J.; Levy, D.; Keaney, J.; Wang, T.; et al. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arter. Thromb. Vasc. Biol. 2013, 33, 1728–1733.
. Cohen, P.; Yang, G.; Yu, X.; Soukas, A.A.; Wolfish, C.S.; Friedman, J.M.; Li, C. Induction of leptin receptor expression in the liver by leptin and food deprivation. J. Biol. Chem. 2005, 280, 10034–10039.
. Kim, J.Y.; van de Wall, E.; Laplante, M.; Azzara, A.; Trujillo, M.E.; Hofmann, S.M.; Schraw, T.; Durand, J.L.; Li, H.; Li, G.; et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Investig. 2007, 117, 2621–2637.
. Banerjee, R.R.; Rangwala, S.M.; Shapiro, J.S.; Rich, A.S.; Rhoades, B.; Qi, Y.; Wang, J.; Rajala, M.W.; Pocai, A.; Scherer, P.E.; et al. Regulation of fasted blood glucose by resistin. Science 2004, 303, 1195–1198
. Qi, Y.; Nie, Z.; Lee, Y.S.; Singhal, N.S.; Scherer, P.E.; Lazar, M.A.; Ahima, R.S. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 2006, 55, 3083–3090.
. Satoh, H.; Nguyen, M.T.; Miles, P.D.; Imamura, T.; Usui, I.; Olefsky, J.M. Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats. J. Clin. Investig. 2004, 114, 224–231.
. Kutlu S., Aydin M., Alcin E., Ozcan M., Bakos J., Jezova D. et al. Leptin modulates nor-adrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats: a microdialysis study. Brain Res. 2010; 1317:87-91.
. Sahin M., Berçik Inal B., Ogreden S., Yigit O., Aral H., Guvenen G. Metabolic profile and insulin resistance in patients with obstructive sleep apnea syndrome. Turk J Med Sci. 2011; 41:443-454.
. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and non-obese humans. Diabetes. 1996;45:695–8.
. Ardekani, J.M.; Nasim, T. and Abbas, A. (2009). Relationships between free leptin and insulin resistance in women with polycystic ovary syndrome. J. Reprod. Med. 7(2): 53-58.
. Lee H, Oh J-Y and Sung Y-A. Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome. Korean J Intern Med 2013; 28:456-463.
. Mirza SS, Shafique K, Shaikh A-R,Khan NA and Qureshi MA. Association between circulating adiponectin levels and polycystic ovarian syndrome. J Ovarian Res 2014; 7:18.
. Seow KM, Hwang JL, Wang PH, Ho LT, Juan CC. Expression of visfatin mRNA in peripheral blood mononuclear cells is not correlated with visfatin mRNA in omental adipose tissue in women with polycystic ovary syndrome. Hum Reprod 2011; 26(10):2869–73.
. Chen X, Jia X, Qiao J, Guan Y, Kang J. Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome. J Mol Endocrinol 2013; 50(2):R21–37.
. Carmina E. Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome. Front Horm Res 2013; 40:40–50.
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