EFFECT OF VITAMIN D DEFICIENCY IN PREGNANT WOMEN

Sadiq Nazim Abdel Amir Hamad; Sarah Ibrahim Mutar Aswad; Hawraa Ayed Halil Khanzeer Al-Qadisiyah; Alina Shahab Qahtan Yahya; Mohammed  Jassim  Mohammed Ali

doi:10.61796/jmgcb.v1i7.781

Authors

Sadiq Nazim Abdel Amir Hamad
Sadeknazim451@gmail.com
AL_muthanna_University College of Science _Department Of biology
Sarah Ibrahim Mutar Aswad University of anbar College of Science Biology department
Hawraa Ayed Halil Khanzeer Al-Qadisiyah University College of Science _Department Of biology
Alina Shahab Qahtan Yahya Al-Mustansiriya University, Bachelor of Life Sciences, Biotechnology
Mohammed Jassim Mohammed Ali Madenat Alelem University College Department of biology

Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology

Articles

July 26, 2024

Downloads

View Article

Abstract
How to Cite
Metrics
References
License

Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non-skeletal benefits of vitamin D (ViD)..

Hamad, S. N. A. A., Aswad, S. I. M., Al-Qadisiyah, H. A. H. K., Yahya, A. S. Q., & Ali, M. . J. . M. (2024). EFFECT OF VITAMIN D DEFICIENCY IN PREGNANT WOMEN. Journal of Medical Genetics and Clinical Biology, 1(7), 260–270. https://doi.org/10.61796/jmgcb.v1i7.781

Download Citation

. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010;202:429.e1-9.

. Dawodu A, Wagner CL. Prevention of vitamin D deficiency in mothers and infants worldwide - a paradigm shift. Paediatr Int Child Health. 2012;32:3-13.

. Souberbielle JC, Body JJ, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recomendations for clinical practice. Autoimmun Rev. 2010;9:709-15.

. Chicote CC, Lorencio FG; Comité de Comunicación de la Sociedad Española de Bioquímica Clínica y Patología Molecular. Vitamina D: una perspectiva actual. Barcelona: Comité de Comunicación de la Sociedad Española de Bioquímica Clínica y Patología Molecular; 2013.

. Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescentes. Pediatrics. 2008;122:1142- 52.

. Masvidal Aliberch RM, Ortigosa Gómez S, Baraza Mendoza MC, Garcia-Algar O. Vitamin D: pathophysiology and clinical applicability in paediatrcs. An Pediatr (Barc). 2012;77:279.e1- 279.e10.

. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Overview of vitamin D. Washington: National Academies Press; 2011.

. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81.

. Cunninghan S, Cameron IT. Consequences of fetal growth restriction during childhood and adult life. Curr Obstet Gynecol. 2003;13:212-7.

. Kim YJ. In utero programming of chronic disease. J Womens Med. 2009;2:48 53.

. Amarasekera M, Prescott SL, Palmer SL. Nutrition in early life, imune- programming and allergies: the role of epigenetics. Asian Pac J Allergy Immunol. 2013;31:175-82.

. McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, Morrison JL. Developmental origins of adults health and disease: the role of periconceptional and fetal nutrition. Basic Clin Pharmacol Toxicol. 2008;102:82-9.

. Jang H, Serra C. Nutrition, Epigenetics, and Diseases. Clin Nutr

. Res. 2014;3:1-8. 14. Hossein–Nezhad A, Holick MF. Optimize dietary intake of Vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012;15: 567-79.

. Hossein–Nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88:720-55

. Hykema MN, Blacuire MJ. Intrauterine effects of maternal smoking on sensitization asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009;6:660-2.

. Sharma S, Chhabra D, Kho AT, Hayden LP, Tantisira KG, Weiss ST. The genomic origins of asthma. Thorax. 2014;69:481-4.

. Hambidge KM, Krebs NF, Westcott JE, Garces A, Goudar SS, Kodkany BS, et al. Preconception maternal nutrition: a multisite randomized controlled trial. BMC Pregnancy Childbirth. 2014;14:111.

. Shrimpton R: Global policy and programme guidance on maternal nutrition: what exists, the mechanisms for providing it, and how to improve them? Paediatr Perinat Epidemiol. 2012;26 (S1):315-25

. Kaushal M, Magon. Vitamin D in pregnancy: a metabolic outlook. Indian J Endocrinol Metab. 2013;17:76-82.

. Taufield PA, Ales KL, Resnick LM, Druzin ML, Gerther JM, Laragh JH. Hypocalciuria in preeclampsia. N Engl J Med. 1987: 316: 715-8.

. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamn D concentration and the risk for gestacional diabetes mellitus. PLoS ONE. 2008;3:e3753.

. Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginose in the first trimester of pregnancy. J Nutr. 2009;139:1157-61.

. Wagner CL, McNeil R, Hamilton SA, Winkler J, Rodriguez Cook C, Warner G, et al. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am J Obstet Gynecol. 2013;208:137e1-13.

. Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. 2009;94:940-5.

. Hillman LS, Haddad JG. Human perinatal vitamin D metabolism I: 25- Hydroxyvitamin D in maternal and cord blood. J Pediatr. 1974;84:742-9.

. American Academy of Pediatrics. Policy statement - ultraviolet radiation: a hazard to children and adolescents. Pediatrics serial on the Internet . 2011;104:328 accessed 29 February 2011 . Available from: http://pediatrics.aappublications.org/

content/early/2011/02/28/peds.2010-3501.abstract.

. Camargo CA, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127:180-7.

. Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr. 2007;85:853-9.

. Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62:68-77.

. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-3. 32. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:538.

. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.

. De la Hunty A, Wallace AM, Gibson S, Viljakainen H, Lamberg-Allardt C, Ashwell M. UK Food Standards Agency Workshop Consensus Report: the choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D

. status for the UK national diet and nutrition survey. Br J Nutr. 2010;104:612-9.

. Gaksch M, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T, et al. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLOS ONE. 2017;12: e0170791. https://doi.org/10.1371/journal.pone.0170791

. Palacios C, Kostiuk LK, Pena-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019;7:Cd008873 https://doi.org/10.1002/14651858.CD008873.pub4. e-pub ahead of print 2019/07/28

. Holick MF. A call to action: pregnant women in-deed require vitamin D supplementation for better health outcomes. J Clin Endocrinol Metab. 2018;104:13– 15. https://doi.org/10.1210/jc. 2018-01108

. Akbari S, Khodadadi B, Ahmadi SAY, Abbaszadeh S, Shahsavar F. Association of vitamin D level and vitamin D deficiency with risk of preeclampsia: a systematic review and updated metaanalysis. Taiwan J Obstet Gynecol. 2018;57:241–7. https://doi.org/10.1016/j.tjog.2018.02.013

. McDonnell SL, Baggerly KA, Baggerly CA, Aliano JL, French CB, Baggerly LL, et al. Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center. PloS

ONE. 2017;12:e0180483–e0180483. https://doi.org/10.1371/journal.pone.0180483

. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL.Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Min

Res. 2011;26:2341–57. https://doi.org/10.1002/jbmr.463

. Rostami M, Tehrani FR, Simbar M, Bidhendi Yarandi R, Minooee S, Hollis BW, et al. Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. J Clin Endocrinol Metab. 2018;103:2936–48. https://doi.org/10.1210/jc.2018-00109

. 42.. Wagner CL, Baggerly C, McDonnell S, Baggerly KA, French CB, Baggerly L. et al. Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009–

rates. J Steroid Biochem Mol Biol. 2016;155:245–51. https://doi.org/ 10.1016/j.jsbmb.2015.10.022.

. Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012;15:567–79. https://doi.org/10.1097/MCO.0b013e3283594978

. Novakovic B, Sibson M, Ng HK, Manuelpillai U, Rakyan V, Down T, et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaterial interface. J Biol Chem. 2009;284:14838–48. https://doi.org/10.1074/jbc.M809542200