ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND LIVER FUNCTION TESTS IN CHILDREN WITH BETA-THALASSEMIAIN THALASSEMIA CENTER OF KUT HOSPITAL
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Background:Thalassemia represents a heterogeneous autosomal recessive hereditary anemia.Ferritin is a 450 KDa soluble protein. It can be found in all of the body's cells, but it's particularly abundant in marrow macrophages, spleen, and liver.
Objective:In patients with β thalassemia major and β thalassemia Intermedia, serum ferritin levels are measured, and their correlation with bilirubin levels, liver enzymes AST (aspartate transaminase) and ALT (alanine transaminase), in beta-thalassemia major and β thalassemia Intermedia.
Patients and Methods:A cross-section study that involved 90 patientsincluded 50 Thalassemia Major (TM) and 40 Thalassemia intermediate(TI). Patients who were randomly chosen for this study would be gathered from the Kut Hospital Thalassemia Center. Every patient's are kid, aged 5 to 17, regardless of gender. Abbott C4000 Architect Additionally, the TSB, ALT, AST, and serum ferritin were determined using the Cobas c 111 analyzer.
Results:The studies include both genders 52.9% of the females had B-thalassemia major and 47.1% had β-thalassemia intermediate, whereas 57.1% of the men had βTM and 42.9% had βTI. There were 37.8% of females and 62.2% of males in the sample.Patients with severe thalassemia exhibited a statistically significant increase in the mean± SD of serum ferritin (4016.54 ± 2500.81 ng/ml) compared to the mean ± SD of β-thalassemia intermedia (1629.48 ± 1235.33 ng/ml), with a p-value of 0.000. Patients with major β-thalassemia had a mean TSB level that was statistically significantly lower (1.32 ± 0.69 mg/dl) than the mean level of β-thalassemia intermedia (2.10 ± 0.86 mg/dl), with a p-value of 0.000. In the B-thalassemia major group, serum hepcidin did not exhibit a statistically significant association with serum ferritin (r=-0.04), while in the B-thalassemia intermedia group, serum ferritin exhibited a statistically significant moderate negative correlation with TSB (r=-0.38), p-value. 0.01.Conclusions:Ferritin levels may be useful in thalassemia syndrome diagnosis and prognosis determination
. Ali EA, AL-Bayati AA, AL-Shaban SA, Ali K. Serum Hepcidin And Ferritin Level Changes In Iraqi Adult Patients With Non-Transfusion Dependent Beta-Thalassemia Major And Intermedia. International Journal of Pharmaceutical Research. 2021 Jan;13(1).
. Zeiny SM. The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital. Journal of the Faculty of Medicine Baghdad. 2016 Jan 3;58(4):366-70.
. Faraj SA. Hemostatic parameters in Thalassemia patients; a single institute experience. Journal of the Faculty of Medicine Baghdad. 2016 Jul 3;58(2):132-5.
. Mettananda S, Higgs DR. Molecular basis and genetic modifiers of thalassemia. Hematology/Oncology Clinics. 2018 Apr 1;32(2):177-91.
. Rooks H, Clark B, Best S, Rushton P, Oakley M, et al . A novel 506 kb deletion causing εγδβ thalassemia. Blood Cells, Molecules, and Diseases. 2012 Oct 15;49(3-4):121-7.
. Alkinani AA, Abbas AP, Faraj AP, Jumaa RM. AN Epidemiological Study of Thalassaemia Patients Attending Thalassaemic Center in Wassit Governorate..2017.
. Apidechkul T, Yeemard F, Chomchoei C, Upala P, Tamornpark R. Epidemiology of thalassemia among the hill tribe population in Thailand. PloS one. 2021 Feb 11;16(2):e0246736.
. Kattamis A, Forni GL, Aydinok Y, Viprakasit V. Changing patterns in the epidemiology of β‐thalassemia. European Journal of Haematology. 2020 Dec;105(6):692-703.
. Cullis JO, Fitzsimons EJ, Griffiths WJ, Tsochatzis E, Thomas DW, British Society for Haematology. Investigation and management of a raised serum ferritin. British journal of haematology. 2018 May;181(3):331-40
. Dignass A, Farrag K, Stein J. Limitations of serum ferritin in diagnosing iron deficiency in inflammatory conditions. International Journal of Chronic Diseases. 2018 Mar 18;2018.
. Camaschella C, Nai A, Silvestri L. Iron metabolism and iron disorders revisited in the hepcidin era. Haematologica. 2020 Feb;105(2):260
. Askarpour M, Djafarian K, Ghaedi E, Sadeghi O, Sheikhi A, et al. Effect of l-carnitine Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Archives of medical research. 2020 Jan 1;51(1):82-94.
. Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochimica et BiophysicaActa (BBA)-General Subjects. 2009 Jul 1;1790(7):694-701.
. Melchiori L, Gardenghi S, Rivella S. β-thalassemia: HiJAKing ineffective erythropoiesis and iron overload. Advances in hematology. 2010;2010.
. EshaghHossaini SK. Association between serum levels of hepcidin and ferritin in patients with thalassemia major and intermedia, the role of iron chelator. Journal of Hematopathology. 2019 Sep;12(3):143-7.
. Kanbour I, Chandra P, Soliman A, De Sanctis V, Nashwan A, et al. Severe liver iron concentrations (LIC) in 24 patients with β-thalassemia major: correlations with serum ferritin, liver enzymes and endocrine complications. Mediterranean journal of hematology and infectious diseases. 2018;10(1).
. Datz, C., Müller, E. and Aigner, E. ‘Iron overload and non-alcoholic fatty liver disease’, Minerva Endocrinologica.(2017), 42(2), pp. 173–183
. Asif M, Manzoor Z, Farooq MS, Kanwal A, Shaheen U, et al. Correlation between serum ferritin level and liver function tests in thalassemic patients receiving multiple blood transfusions. International Journal of Research in Medical Sciences. 2014 Jul;2(3):988.
. Jwaid SH, GATA AM. Comparison study of major thalassemia, thalassemia intermedia of Iraqi patients and control groups for effectiveness of liver enzymes. Medico-Legal Update. 2020 Mar 1;20(1):1181-4.
. Sultana N, Sadiya S, Rahman MH. Correlation between serum bilirubin and serum ferritin level in thalassaemia patients. Bangladesh Journal of Medical Biochemistry. 2011;4(2):6-12.
. Harish G, Pasha S. Correlation of serum ferritin levels with liver function tests and anthropometric measurements in transfusion dependent beta-thalassemia major children: a cross sectional study. Pediatric Oncall Journal. 2019;16(4):101-4.
. Suman RL, Sanadhya A, Meena P, Goyal S. Correlation of liver enzymes with serum ferritin levels in β-thalassemia major. Int J Res Med Sci 2016; 4:3271-)
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