CLINICAL APPLICATIONS OF STEM CELL THERAPY IN THE FIGHT AGAINST CANCER
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Stem cell therapy is emerging as a novel approach in the fight against cancer, with over 300 clinical trials exploring various stem cell types, including embryonic, adult, fetal, amniotic fluid, and human embryonic-like stem cells. These trials aim to treat a range of diseases, notably cancer, by leveraging the regenerative capabilities of stem cells. Cancer stem cells (CSCs), a subpopulation within tumors, are integral to tumor growth and resistance to conventional treatments due to their self-renewal properties. Innovative strategies, such as suicide gene therapy using genes like Cytosine Deaminase (CD), show promise in targeting these CSCs and enhancing treatment outcomes. This review discusses the dual role of stem cells in cancer therapy, highlighting their potential to both promote and inhibit tumor development, and underscores the need for well-characterized therapeutic stem cell banks equipped with anti-tumor genes. Future research directions and the potential of stem cell-based therapies to revolutionize cancer treatment are also explored.
Ullah M. Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes. J Biomed Allied Res. 2020 Jun;2(1):013. doi: 10.37191/mapsci-2582-4937-2(1)-013. Epub 2020 Mar 16. PMID: 33554055; PMCID: PMC7861576.
Lodi D, Iannitti T, Palmieri B. Stem cells in clinical practice: applications and warnings. J Exp Clin Cancer Res. 2011 Jan 17;30(1):9. doi: 10.1186/1756-9966-30-9. PMID: 21241480; PMCID: PMC3033847.
Kabat M, Bobkov I, Kumar S, Grumet M. Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range? Stem Cells Transl Med. 2020 Jan;9(1):17-27. doi: 10.1002/sctm.19-0202. Epub 2019 Dec 5. PMID: 31804767; PMCID: PMC6954709.
Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res. 2021 Jan;52(1):93-101. doi: 10.1016/j.arcmed.2020.08.006. Epub 2020 Sep 22. PMID: 32977984.
Bandhavkar S. Cancer stem cells: a metastasizing menace! Cancer Med. 2016 Apr;5(4):649-55. doi: 10.1002/cam4.629. Epub 2016 Jan 15. PMID: 26773710; PMCID: PMC4831283.
Fleifel D, Rahmoon MA, AlOkda A, Nasr M, Elserafy M, El-Khamisy SF. Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's. J Genet Eng Biotechnol. 2018 Dec;16(2):427-432. doi: 10.1016/j.jgeb.2018.09.002. Epub 2018 Dec 10. PMID: 30733756; PMCID: PMC6354001.
S Franco S, Szczesna K, Iliou MS, Al-Qahtani M, Mobasheri A, Kobolák J, Dinnyés A. In vitro models of cancer stem cells and clinical applications. BMC Cancer. 2016 Sep 30;16(Suppl 2):738. doi: 10.1186/s12885-016-2774-3. PMID: 27766946; PMCID: PMC5073996.
Aldoghachi AF, Chong ZX, Yeap SK, Cheong SK, Ho WY, Ong AHK. Stem Cells for Cancer Therapy: Translating the Uncertainties and Possibilities of Stem Cell Properties into Opportunities for Effective Cancer Therapy. Int J Mol Sci. 2023 Jan 5;24(2):1012. doi: 10.3390/ijms24021012. PMID: 36674525; PMCID: PMC9864033.
Mirzapour, Tooba & Ibrahim, Tengku & Movahedin, Mansoureh & Haron, Abd Wahid & Siraj, Siti & Koruji, Morteza & Mohamadreza, Nowroozi & Shahram, Rafieian. (2011). Stem Cells Research and its Applications: A Review. Journal of Applied Sciences. 11. 10.3923/jas.2011.163.173.
Botelho M, Alves H. Significance of Cancer Stem Cells in Anti-Cancer Therapies. Int J Immunother Cancer Res. 2016;2(1):14-16. Epub 2016 Dec 31. PMID: 28191547; PMCID: PMC5298826.
Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED. Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae. 2015 Oct-Dec;7(4):46-55. PMID: 26798491; PMCID: PMC4717249.
Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED. Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae. 2015 Oct-Dec;7(4):46-55. PMID: 26798491; PMCID: PMC4717249.
Xuan, Xiuyun & Tian, Chunxia & Zhao, Mengjie & Sun, Yanhong & Huang, Changzheng. (2021). Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance. Cancer Cell International. 21. 10.1186/s12935-021-02300-4.
Frisbie L, Buckanovich RJ, Coffman L. Carcinoma-Associated Mesenchymal Stem/Stromal Cells: Architects of the Pro-tumorigenic Tumor Microenvironment. Stem Cells. 2022 Aug 25;40(8):705-715. doi: 10.1093/stmcls/sxac036. PMID: 35583414; PMCID: PMC9406606.
Emami Nejad A, Najafgholian S, Rostami A, Sistani A, Shojaeifar S, Esparvarinha M, Nedaeinia R, Haghjooy Javanmard S, Taherian M, Ahmadlou M, Salehi R, Sadeghi B, Manian M. The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment. Cancer Cell Int. 2021 Jan 20;21(1):62. doi: 10.1186/s12935-020-01719-5. PMID: 33472628; PMCID: PMC7816485.
López de Andrés J, Griñán-Lisón C, Jiménez G, Marchal JA. Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment. Journal of hematology & oncology. 2020 Oct 15;13(1):136. springer.com
Chu DT, Nguyen TT, Tien NL, Tran DK, Jeong JH, Anh PG, Thanh VV, Truong DT, Dinh TC. Recent progress of stem cell therapy in cancer treatment: molecular mechanisms and potential applications. Cells. 2020 Feb 28;9(3):563. mdpi.com
Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F, Cui H. Targeting cancer stem cell pathways for cancer therapy. Signal transduction and targeted therapy. 2020 Feb 7;5(1):8. nature.com
Sng J, Lufkin T. Emerging stem cell therapies: treatment, safety, and biology. Stem Cells Int. 2012;2012:521343. doi: 10.1155/2012/521343. Epub 2012 Aug 2. PMID: 22919402; PMCID: PMC3419439.
Liu G, David BT, Trawczynski M, Fessler RG. Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications. Stem Cell Rev Rep. 2020 Feb;16(1):3-32. doi: 10.1007/s12015-019-09935-x. PMID: 31760627; PMCID: PMC6987053.
Ebrahimi M, Forouzesh M, Raoufi S, Ramazii M, Ghaedrahmati F, Farzaneh M. Differentiation of human induced pluripotent stem cells into erythroid cells. Stem Cell Res Ther. 2020 Nov 16;11(1):483. doi: 10.1186/s13287-020-01998-9. PMID: 33198819; PMCID: PMC7667818.
Fleifel D, Atef Rahmoon M, AlOkda A, Nasr M et al. Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s. 2018. ncbi.nlm.nih.gov
Quaglino E, Cavallo F, Conti L. Cancer stem cell antigens as targets for new combined anti-cancer therapies. The international journal of biochemistry & cell biology. 2020 Dec 1;129:105861. unito.it
Dalmizrak A, Dalmizrak O. Mesenchymal stem cell-derived exosomes as new tools for delivery of miRNAs in the treatment of cancer. Frontiers in Bioengineering and Biotechnology. 2022 Sep 26;10:956563. frontiersin.org
Hayat H, Hayat H, Dwan BF, Gudi M, Bishop JO, Wang P. A concise review: the role of stem cells in cancer progression and therapy. OncoTargets and therapy. 2021 Apr 20:2761-72. tandfonline.com
Poulos J. The limited application of stem cells in medicine: a review. 2018. ncbi.nlm.nih.gov
Daniel Aschettino J, Victor Szerszunowicz J, William Keaffer L, N. Dalton-Petillo S. Stem Cells and Society. 2012. [PDF]
Chang C, Yan J, Yao Z, Zhang C, Li X, Mao HQ. Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies. Advanced healthcare materials. 2021 Apr;10(7):2001689. nih.gov
Zhang T, Lin R, Wu H, Jiang X et al. Mesenchymal stem cells: A living carrier for active tumor-targeted delivery. Advanced Drug Delivery Reviews. 2022. researchgate.net
Zhang F, Guo J, Zhang Z, Qian Y, Wang G, Duan M, Zhao H, Yang Z, Jiang X. Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy. Cancer letters. 2022 Feb 1;526:29-40. sciencedirect.com
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