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Abstract
Objective: This study aimed at investigating the association of serum vitamin D and superoxide dismutase level in women with polycystic ovary syndrome (PCOS) as well as non-PCOS healthy ovulatory women. Methods: A total of 20 patients with polycystic ovaries and 20 of their age matched healthy control participates was included in this study. The patient samples were collected from women who reproductive age between 18 and 40 with PCOS. Results: The results of the current study showed a high level of SOD enzyme concentration versus decrease in the level of vitamin D in the PCOS patients compared to the healthy group. Conclusion: There is an opposite effect of superoxide dismutase level and vitamin D on polycystic ovary syndrome (PCOS).
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References
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- . J. K. Strzelczyk and T. Wielkoszyński, "The Activity of Antioxidant Enzymes in Colorectal Adenocarcinoma and Corresponding Normal Mucosa," Acta Biochimica Polonica, vol. 59, no. 4, pp. 1-9, Nov. 2012.
- . M. Foretz, B. Guigas, L. Bertrand, M. Pollak, and B. Viollet, "Metformin: From Mechanisms of Action to Therapies," Cell Metabolism, vol. 20, no. 6, pp. 953-966, Dec. 2014.
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References
. H. S. Jabbar, "Current of Polycystic Ovary Syndrome in Women in Al-Muthanna Governorate," Insulin, vol. 17, no. 18, pp. 19, 2020.
. F. R. Cheng, H. X. Cui, J. L. Fang, K. Yuan, and Y. Guo, "Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus," Molecules, vol. 24, no. 8, pp. 1454, Jan. 2019.
. A. C. Tecalco-Cruz, D. G. Ríos-López, G. Vázquez-Victorio, R. E. Rosales-Alvarez, and M. Macías-Silva, "Transcriptional Cofactors Ski and SnoN Are Major Regulators of the TGF-β/Smad Signaling Pathway in Health and Disease," Signal Transduction and Targeted Therapy, vol. 3, no. 1, pp. 1-5, Jun. 2018.
. W. Li, A. D. Kandhare, A. A. Mukherjee, and S. L. Bodhankar, "Hesperidin, a Plant Flavonoid, Accelerated the Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats: Role of TGF-ß/Smads and Ang1/Tie-2 Signaling Pathways," EXCLI Journal, vol. 17, pp. 399, 2018.
. F. Rohde, B. Schusser, T. Hron, H. Farkašová, J. Plachý, and S. Härtle, "Characterization of Chicken Tumor Necrosis Factor-α, a Long-Missed Cytokine in Birds," Frontiers in Immunology, vol. 9, pp. 605, Apr. 2018.
. N. Parameswaran and S. Patial, "Tumor Necrosis Factor-α Signaling in Macrophages," Critical Reviews™ in Eukaryotic Gene Expression, vol. 20, no. 2, pp. 1-10, 2010.
. H. H. Harith, M. J. Morris, and M. M. Kavurma, "On the TRAIL of Obesity and Diabetes," Trends in Endocrinology & Metabolism, vol. 24, no. 11, pp. 578-587, Nov. 2013.
. G. Tornese and V. Tisato, "Serum TRAIL Levels Increase Shortly After Insulin Therapy and Metabolic Stabilization in Children with Type 1 Diabetes Mellitus," Acta Diabetologica, vol. 52, no. 5, pp. 1003-1006, Oct. 2015.
. O. Micheau, "Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation," International Journal of Molecular Sciences, vol. 19, no. 3, pp. 715, Mar. 2018.
. C. C. Lu, F. J. Tang, U. Yoichiro, G. H. Kou, and S. N. Chen, "Yeast Infection in Prawns Macrobrachium Rosenbergii (De Man)," Acta Zoologica Taiwanica, vol. 8, pp. 33-45, 1997.
. M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari, C. M. Gordon, D. A. Hanley, R. P. Heaney, and C. M. Weaver, "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline," The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 7, pp. 1911-1930, Jul. 2011.
. M. L. LeFevre and US Preventive Services Task Force, "Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement," Annals of Internal Medicine, vol. 162, no. 2, pp. 133-140, 2015.
. P. Bordelon, M. V. Ghetu, and R. C. Langan, "Recognition and Management of Vitamin D Deficiency," American Family Physician, vol. 80, no. 8, pp. 841-846, 2009.
. R. L. Rosenfield and D. A. Ehrmann, "The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited," Endocrine Reviews, vol. 37, no. 5, pp. 467-520, 2016.
. P. Skowrońska, E. Pastuszek, W. Kuczyński, M. Jaszczoł, P. Kuć, G. Jakiel, and K. Łukaszuk, "The Role of Vitamin D in Reproductive Dysfunction in Women—A Systematic Review," Annals of Agricultural and Environmental Medicine, vol. 23, no. 4, pp. 1-10, 2016.
. J. M. McCord and I. Fridovich, "Superoxide Dismutase: An Enzymic Function for Erythrocuprein (Hemocuprein)," Journal of Biological Chemistry, vol. 244, no. 22, pp. 6049-6055, Nov. 1969.
. Y. Ōyanagui, "Reevaluation of Assay Methods and Establishment of Kit for Superoxide Dismutase Activity," Analytical Biochemistry, vol. 142, no. 2, pp. 290-296, Nov. 1984.
. W. F. Beyer Jr and I. Fridovich, "Assaying for Superoxide Dismutase Activity: Some Large Consequences of Minor Changes in Conditions," Analytical Biochemistry, vol. 161, no. 2, pp. 559-566, Mar. 1987.
. M. Katerji, M. Filippova, and P. Duerksen-Hughes, "Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field," Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1-29, Mar. 2019.
. C. Beauchamp and I. Fridovich, "Superoxide Dismutase: Improved Assays and an Assay Applicable to Acrylamide Gels," Analytical Biochemistry, vol. 44, no. 1, pp. 276-287, Nov. 1971.
. J. K. Strzelczyk and T. Wielkoszyński, "The Activity of Antioxidant Enzymes in Colorectal Adenocarcinoma and Corresponding Normal Mucosa," Acta Biochimica Polonica, vol. 59, no. 4, pp. 1-9, Nov. 2012.
. M. Foretz, B. Guigas, L. Bertrand, M. Pollak, and B. Viollet, "Metformin: From Mechanisms of Action to Therapies," Cell Metabolism, vol. 20, no. 6, pp. 953-966, Dec. 2014.
. S. Y. Rhee and H. J. Kim, "Monotherapy in Patients with Type 2 Diabetes Mellitus," Diabetes & Metabolism Journal, vol. 41, no. 5, pp. 349-356, Oct. 2017.
. A. S. Mehanna, "Insulin and Oral Antidiabetic Agents," American Journal of Pharmaceutical Education, vol. 69, no. 5, pp. 1-10, Sep. 2005.
. A. K. Seleem, A. A. El Refaeey, D. Shaalan, Y. Sherbiny, and A. Badawy, "Superoxide Dismutase in Polycystic Ovary Syndrome Patients Undergoing Intracytoplasmic Sperm Injection," Journal of Assisted Reproduction and Genetics, vol. 31, pp. 499-504, 2014.