DIRECT EFFECT OF COMORBID MENTAL DISORDERS ON THE CLINICAL COURSE OF ALCOHOLISM
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Objective: This study aims to investigate the direct effect of comorbid mental disorders on the clinical course of alcoholism, emphasizing the complexities involved in diagnosis, treatment, and rehabilitation. Method: A comprehensive analysis was conducted through a cross-sectional study involving patients diagnosed with alcohol use disorder (AUD) and co-occurring mental health conditions. Data were collected using standardized psychiatric assessments and clinical evaluations from both narcology and psychiatry specialists. Results: The findings reveal that the presence of comorbid mental disorders significantly exacerbates the severity and chronicity of alcoholism, leading to poorer treatment outcomes, increased relapse rates, and heightened resistance to standard therapeutic interventions. Patients with dual diagnoses exhibited more complex clinical profiles, necessitating integrated and multidisciplinary treatment approaches. Novelty: This study highlights the critical need for dual-specialist involvement in the management of AUD with comorbid mental disorders, offering new insights into integrated treatment frameworks that can enhance clinical outcomes and reduce the burden of relapse.
Х. Н. Мухитдинова, ‘ЦИРКАДНЫЙ РИТМ СИСТОЛИЧЕСКОГО АРТЕРИАЛЬНОГО ДАВЛЕНИЯ В ЗАВИСИМОСТИ ОТ ТЯЖЕСТИ ТЯЖЕЛОЙ СОЧЕТАННОЙ ЧЕРЕПНО-МОЗГОВОЙ ТРАВМЫ ДО ТРЕХ ЛЕТ’, in Высшая школа: научные исследования, Crossref. doi: 10.34660/inf.2022.68.83.182.
Ц. ХЭ, ‘ОБЗОР ИССЛЕДОВАНИЙ ПО ОРГАНИЧЕСКОМУ МАРКСИЗМУ КИТАЙСКИХ АКАДЕМИЧЕСКИХ КРУГОВ ЗА ПОСЛЕДНИЕ ГОДЫ’, in ГЛОБАЛИСТИКА-2023, ISOASPSH of N.D. Kondratieff, Nov. 2024. doi: 10.46865/978-5-901640-41-8-2024-563-563.
K. Verma Anupma Verma, ‘Stress among Teenagers is Underlying Psychometric Factor for Causing Onset of Anxiety at an Early Age’, International Journal of Science and Research (IJSR), vol. 12, no. 6, pp. 463–469, Jun. 2023, doi: 10.21275/sr23601193427.
Yu. V Zhitkova, ‘Morphofunctional bases for the development of vascular cognitive and emotional disorders’, Neurology, Neuropsychiatry, Psychosomatics, vol. 9, no. 2, pp. 40–45, Jan. 2017, doi: 10.14412/2074-2711-2017-2-40-45.
A. Matthews, R. A. Kramer, and L. Mitan, ‘Eating Disorder Severity and Psychological Morbidity in Adolescents with Anorexia Nervosa or Atypical Anorexia Nervosa and Premorbid Overweight/Obesity’, Feb. 2021, doi: 10.21203/rs.3.rs-210417/v1.
C. Guerri, ‘Neuroanatomical and Neurophysiological Mechanisms Involved in Central Nervous System Dysfunctions Induced by Prenatal Alcohol Exposure’, Alcoholism: Clinical & Experimental Research, vol. 22, no. 2, p. 15, Apr. 1998, doi: 10.1097/00000374-199804000-00003.
G. Vittadini, ‘ALCOHOLIC POLYNEUROPATHY: A CLINICAL AND EPIDEMIOLOGICAL STUDY’, Alcohol and Alcoholism, vol. 36, no. 5, pp. 393–400, Sep. 2001, doi: 10.1093/alcalc/36.5.393.
N. A. Tsalikova and A. T. Manukyan, ‘The effectiveness of the use of adaptogenic drugs for adaptation of patients with depressive neurosis to fixed orthopedic prosthetics.’, Stomatology for All / International Dental review, no. 1(110), pp. 54–57, Mar. 2025, doi: 10.35556/idr-2025-1(110)54-57.
R. A. Al-Eryani and L. A. Al- Najjar, ‘Assessment of Salivary Immunoglobulin a and Lysozyme Levels and Their Relation to Dental Caries Status in a Group of Yemeni Asthmatic Children’, Saudi Journal of Oral and Dental Research, vol. 10, no. 01, pp. 43–51, Jan. 2025, doi: 10.36348/sjodr.2025.v10i01.007.
V. N. Shishkova, ‘Psycho-emotional state of patients with chronic non-communicable diseases: important aspects of therapy’, Meditsinskiy sovet = Medical Council, no. 13, pp. 256–262, Aug. 2023, doi: 10.21518/ms2023-230.
M. Pontillo, D. Menghini, and S. Vicari, ‘Neurocognitive profile and onset of psychosis symptoms in children, adolescents and young adults with 22q11 deletion syndrome: A longitudinal study’, Schizophr Res, vol. 208, pp. 76–81, Jun. 2019, doi: 10.1016/j.schres.2019.04.012.
A. Ferbert and K. Willmes, ‘The Relevance of Neurological and Functional Outcome Scales for Acute Stroke Trials’, in Thrombolytic Therapy in Acute Ischemic Stroke II, Springer Berlin Heidelberg, 1993, pp. 217–223. doi: 10.1007/978-3-642-78061-5_31.
H. J. Little, ‘The role of calcium channels in drug dependence’, Drug Alcohol Depend, vol. 38, no. 2, pp. 173–194, May 1995, doi: 10.1016/0376-8716(95)01121-e.
C. A. Benson, ‘Reply’, Clinical Infectious Diseases, vol. 18, no. 1, p. 129, Jan. 1994, doi: 10.1093/clinids/18.1.129.
P. Chassagne and S. N’Guyen, ‘Hydratation et natrémie’, in Gériatrie, Elsevier, 2023, pp. 356–360. doi: 10.1016/b978-2-294-77815-5.00039-1.
C. S. Copeland, ‘Commentary on Craft et al.: Drug contaminants and substitutions in illicit vapes represent a major health risk’, Addiction, Jan. 2025, doi: 10.1111/add.16777.
N. Nacca, D. Vatti, R. Sullivan, P. Sud, M. Su, and J. Marraffa, ‘The Synthetic Cannabinoid Withdrawal Syndrome’, J Addict Med, vol. 7, no. 4, pp. 296–298, Jul. 2013, doi: 10.1097/adm.0b013e31828e1881.
A. Abdullah Solaiman, ‘Diabetes and Ischemic Stroke, An Assessment of the Most Recent Research’, Journal of Medical Science and clinical Research, vol. 12, no. 01, pp. 69–72, Jan. 2024, doi: 10.18535/jmscr/v12i01.11.
B. Sichère, ‘Shakespeare, lointain et proche’, in Shakespeare, lointain et proche, Hermann, 2023, pp. 223–229. doi: 10.3917/herm.vigna.2023.01.0223.
L. Jarrell, ‘Therapeutic management of atopic dermatitis’, Nurse Pract, vol. 49, no. 6, pp. 39–46, May 2024, doi: 10.1097/01.npr.0000000000000183.
R. L. Nail and L. M. Dean, ‘Drug abuse: A manifestation of the cyclic nature of human behavior’, Drug Alcohol Depend, vol. 1, no. 6, pp. 429–434, Oct. 1976, doi: 10.1016/0376-8716(76)90007-7.
I. Belokrylov, ‘The Effectiveness of Psychoanalytic Psychotherapy in the Somatoform Disorders Treatment’, Feb. 2018, doi: 10.26226/morressier.5a7070ded462b80290b56a4a.
E. Alleyne and J. L. Wood, ‘Gang involvement: psychological and behavioral characteristics of gang members, peripheral youth, and nongang Youth’, Aggress Behav, vol. 36, no. 6, pp. 423–436, Aug. 2010, doi: 10.1002/ab.20360.
M. M. Mirkhamzaevna and A. Viloyathon, ‘INTRODUCTION OF PATIENTS WITH CHRONIC CEREBROVASCULAR DISEASE CAUSED BY ARTERIAL HYPOTENSION, IN PATIENTS OF YOUNG AGE’, Frontline Medical Sciences and Pharmaceutical Journal, vol. 02, no. 04, pp. 47–52, Apr. 2022, doi: 10.37547/medical-fmspj-02-04-07.
А. А. Соловьёв, ‘Основные полномочия Высшего совета магистратуры Алжирской Народной Демократической Республики’, Вестник Арбитражного суда Московского округа, no. 1, pp. 86–93, Apr. 2022, doi: 10.46279/asmo.2022.21.93.006.
Y. Zhan and Y. Xia, ‘Study On Rehabilitation Treatment of Patients with Lumbar Disc Herniation by Acupuncture and Massage’, Highlights in Science, Engineering and Technology, vol. 45, pp. 329–333, Apr. 2023, doi: 10.54097/hset.v45i.7485.
D. Agrawal, E. M. Shajil, Y. S. Marfatia, and R. Begum, ‘Study on the Antioxidant Status of Vitiligo Patients of Different Age Groups in Baroda’, Pigment Cell Res, vol. 17, no. 3, pp. 289–294, May 2004, doi: 10.1111/j.1600-0749.2004.00149.x.
J. Corcoran, ‘Anorexia Nervosa and Bulimia Nervosa’, in Mental Health Treatment for Children and Adolescents, Oxford University Press, 2010, pp. 159–180. doi: 10.1093/acprof:oso/9780195375718.003.0008.
A. S. Hazell, ‘CHAPTER 32. Wernicke’s Encephalopathy caused by Thiamine (Vitamin B1) Deficiency’, in B Vitamins and Folate, Royal Society of Chemistry, 2012, pp. 538–552. doi: 10.1039/9781849734714-00538.
O. O. Andronnikova, ‘Psychological characteristics of adolescents prone to suicidal behavior’, in General question of world science, in gqws. General question of world science, 2024, pp. 19–25. doi: 10.18411/gqws-01-2024-04.
O. H. Al-Jiffri, ‘Association Between the Immune System Response and Body Mass Index Among Hepatitis C Virus Saudi Patients’, European Journal of Basic Medical Sciences, vol. 5, no. 4, pp. 61–66, Dec. 2015, doi: 10.21601/ejbms/9174.
Y. Wang, ‘PRC’s Public Diplomacy Practice in Central Asia: Current Situation, Challenges and Prospects’, Moscow University Bulletin of World Politics, vol. 14, no. 4, pp. 145–172, Mar. 2023, doi: 10.48015/2076-7404-2022-14-4-145-172.
G. Singh and L. Samavedham, ‘Unsupervised learning based feature extraction for differential diagnosis of neurodegenerative diseases: A case study on early-stage diagnosis of Parkinson disease’, J Neurosci Methods, vol. 256, pp. 30–40, Dec. 2015, doi: 10.1016/j.jneumeth.2015.08.011.
P.-A. Fabre and B. Pierre, ‘Les Jésuites’, in Les Jésuites, Bouquins, 2023, pp. 1133–1136. doi: 10.3917/bouq.fabre.2022.01.1133.
Y. Li and X. Liu, ‘Efficacy and safety of non-invasive brain stimulation in combination with antidepressants in adolescents with depression: a systematic review and meta-analysis’, Front Psychiatry, vol. 15, Feb. 2024, doi: 10.3389/fpsyt.2024.1288338.
K. Persaud and P. Hemmer, ‘The dynamics of fidelity over the time course of long-term memory’, Cogn Psychol, vol. 88, pp. 1–21, Aug. 2016, doi: 10.1016/j.cogpsych.2016.05.003.
I. Rubina, ‘Legal Regulation of Medical Checkup of Orphaned Children and Children Left Without Parental Care: New Order — Old Problems’, Journal of Russian Law, vol. 27, no. 8, p. 70, 2023, doi: 10.61205/jrp.2023.092.
H. P V, ‘Rights of Children without Parental Care’, International Journal of Science and Research (IJSR), vol. 13, no. 2, pp. 213–215, Feb. 2024, doi: 10.21275/sr24202053434.
L. Y. Davidyan et al., ‘Specific features of psycho-emotional states of working women during pregnancy’, Electronic Journal of General Medicine, vol. 15, no. 6, Nov. 2018, doi: 10.29333/ejgm/99829.
O. J. Oyeku, D. Mitchell, H. Elwood, and J. Durkin, ‘A case of pembrolizumab-induced pigmented purpuric dermatosis’, JAAD Case Rep, vol. 34, pp. 77–79, Apr. 2023, doi: 10.1016/j.jdcr.2023.02.008.
S.-H. Lee, ‘Symptoms and Signs of Hemorrhagic Stroke’, in Stroke Revisited: Hemorrhagic Stroke, Springer Singapore, 2018, pp. 103–108. doi: 10.1007/978-981-10-1427-7_8.
A. Cherniak, ‘SCHIZOPHRENOMORPHICAL PSYCHOSIS IN THE PERIOD OF TRAUMA: CLINICAL PICTURE AND METHODS’, in SCIENTIFIC PRACTICE: MODERN AND CLASSICAL RESEARCH METHODS, European Scientific Platform, Sep. 2022. doi: 10.36074/logos-16.09.2022.39.
J. Mrizak, S. A. M. I. Ouanes, M. Lakhal, R. Y. M. Rafrafi, and Z. El-Hechmi, ‘EPA-1205 – Remission and recovery in schizophrenia: associated socio-demographic and clinical features’, European Psychiatry, vol. 29, p. 1, 2014, doi: 10.1016/s0924-9338(14)78451-2.
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