INCIDENCE OF SEPSIS IN CHILDREN UNDER 5 YEARS OLD WITHIN KIRKUK PROVINCE
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Objectives: Medical researches on septicemia, particularly, in most susceptible age group of children i.e. newborns and young infants in Iraq are scanty. The aim of this study is to assess the incidence of blood poisoning via hematological parameters in children under 5 years old within Kirkuk Province. Methodology: Only 120 children aged 1-60 months admitted to hospital on suspicion of blood poisoning were selected and compared with other 40 healthy children of similar ages used as control. Results: Almost 42.5% of suspected cases admitted to hospital were diagnosed sepsis positive. Over 80% of affected sepsis cases were in children aged 1-18 months old but dropped down as the age advanced. The main blood parameters i.e. leucocytes (WBC), erythrocytes (RBC), hemoglobin (Hb%), Lymphocytes (L), Blood platelets (PLT) were significantly (p≤0.05-0.0001) affected up and down in sepsis patients in comparison with counterpart children. Novelty: It is concluded that the newborn and infants are more susceptible to infection than older ages due to the immaturity of the immune system in these babies, artificial rather than breast feeding, negligence and inexperience of mothers and deficiency of hygienic parameters applied. Early and regular health checkup of newborn babies under 5 years old by pediatricians deems mandatory to promote health measurements and reduce children mortality.
M. Singer, C.S. Deutschman, CW Seymour, M. Shankar-Hari, D. Annane, M. Bauer, R. Bellomo, G.R. Bernard, J.D. Chiche, C.M. Coopersmith, R.S. Hotchkiss, M.M. Levy, J.C. Marshall, G.S. Martin, S.M. Opal, G.D. Rubenfeld, T. van der Poll, J.L. Vincent, and D.C. Angus. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA., vol. 315, no. 8, pp. 801-810; 2016. doi: 10.1001/jama.2016.0287.
R.S. Watson, J.A. Carcillo, W.T. Linde-Zwirble, G. Clermont, J. Lidicker, and D.C. Angus. The epidemiology of severe sepsis in children in the United States. American Journal of Respiratory and Critical Care Medicine; vol. 167, no. 5 pp. 695-701, 2003.
World Health Statistics (WHO) report. Monitoring health for the SDGs, sustainable development goals; 2020. Also available at: https://iris.who.int/bitstream/handle/10665/332070/9789240005105-eng.pdf
UNICEF. Child mortality report. Also available at: https://data.unicef.org/resources/child-mortality-report-2021/
O. Akinseye, C.R. Popescu, M. Chiume-Kayuni, M.A. Irvine, N. Lufesi, T. Mvalo, N. Kissoon, M.O. Wiens, and P.M. Lavoie. World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study. Ed. Musa Mohammed Ali PLOS Glob Public Health. vol. 3, no. 11e; 2023. 0001990. doi: 10.1371/journal.pgph.0001990. Also available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC10662722/
K. North, M. Gao, G. Allen, and A.C.C. Lee. Breastfeeding in a Global Context: Epidemiology, Impact, and Future Directions. Clinical Therapeutic; vol. 44, no. 2; 2022.
L. Yang, R. Kelishadi, M.H. Young, A. Khadilkar, N. Tadeusz, et al. American Academy of Pediatrics Guideline on Hypertension Prevalence Compared With the Fourth Report in an International Cohort. Hypertension; vol. 74, no. 6; pp. 1343-1348; Also available at: https://pubmed.ncbi.nlm.nih.gov/31630571/
S.R. Ali, H. Khan, H and A. Mahmood. Impact of conflict on healthcare systems in post-war regions. Journal of Global Health; 10(2): 235-244; 2018.
R.K. Saleh, A.M. Ahmed and R.H. Jaffar. Antibiotic resistance profiles of pathogenic bacteria in septicemia. Iraqi Journal of Medical Sciences; vol. 18, no. 3; pp. 175-183; 2020.
DAG Lor. A bacteriological and histochemical study of the surgically removed appendix within Kirkuk province. MSc Thesis, University of Kirkuk, Iraq; 2018.
C. Fleischmann-Struzek and K. Rudd. Challenges of assessing the burden of sepsis. Med Klin Intensivmed Notfmed. vol. 118, no. S2; pp. 68-74; 2023. doi: 10.1007/s00063-023-01088-7. https://www.google.com/search?q=Fleischmann.
M. Klog, R.M. Ghobrial, E. Kuchar, S. Lewicki, J.K. Kubiak. Development of child immunity in the context of COVID-19 pandemic. Clin Immunology; vol. 13; pp. 217-; 2020. 108510. doi: 10.1016/j.
I. Lakbar, S. Einav, N. Lalevée, I. Martin-Loeches, B. Pastene, M. Le. Interactions between gender and sepsis, implications for the future. Microorganisms. vol. 11, no. 3; pp. 746- ; 2023. doi: 10.3390/microorganisms11030746.
D.S. Chabot-Richards, and T.I. George. Leukocytosis. International Journal of Lab Hematology. vol. 36, no. 3; pp. 279-288. 2014. Also available at: https://www.ncbi.nlm.nih.gov/books/NBK560882/
R. Itzykson, P. Fenaux, D. Bowen, N.C.P. Cross, J. Cortes, T. De Witte, et al. Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the European Hematology Association and the European Leukemia Net. Hemasphere. vol. 2, no. 6; pp. e150. 2018. Also available at: https://www.ncbi.nlm.nih.gov/books/NBK560882/
N. Abramson, and B. Melton. Leukocytosis: “Basics of Clinical” assessment. Am Fam Physician. Vol. 62, no. 9, pp. 2053-2060; 2000.
L. Modglin. Phagocytes: Functions and Importance. Medically Reviewed, Part of Blood Basics; 2024. Also available at: https://www.patientpower.info/navigating-cancer/phagocytes.
R. Wang, C. Lan, K. Benlagha, N.O.S. Camara, H. Miller, M.K. Masato et al. The interaction of innate immune and adaptive immune system. 2024. 1st Ed. Also available at: https://onlinelibrary.wiley.com/doi/full/10.1002/mco2.714. https://doi.org/10.1002/mco2.714
S. Bäckman, A. Larjo, J. Soikkeli, J. Castrén, J. Ihalainen, and M. Syrjälä. Season and time of day affect capillary blood hemoglobin level and low hemoglobin deferral in blood donors: analysis in a national blood bank. Transfusion. vol. 56, no. 6. 2016. Also available at: https://onlinelibrary.wiley.com/action/doSearch?AllField=Low+in+hemoglobin+in+blood
J. Zhu, Y. Dong, P. Liao, X. Yin, J. He, and L. Guo. Prognostic value of hemoglobin in patients with sepsis: A systematic review and meta-analysis. Heart and Lung. vol. 64, pp. 93-99. 2014.
W. Sae-Lee, C.L. McCafferty,E.J. Verbeke, P.C. Havugimana, O.P. Ophelia D.C. McWhite, et al. The protein organization of a red blood cell. Cell Rep. vol. 40, no. 3; pp. 111103. 2022. doi: 10.1016/j.celrep.PMCID: PMC9764456 NIHMSID: NIHMS1856933 PMID: 35858567
World Health Organization (2024). “Sepsis: A global priority". Also available at: https://www.who.int/news-room/fact-sheets/detail/sepsis
A. El-Said, R. Patil, B. Leone, A. Gulani, M.P. Abrams, A. Momin, and J. Simms-Cendan. Assessing the Impact of Demographic Factors on Presenting Conditions or Complaints among Internal Medicine Patients in an Underserved Population in Central Florida. Cureus; vol. 14, no. (8); 2022.e27811. doi: 10.7759/cureus.27811
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